DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Octbeta2R and ser-7

DIOPT Version :9

Sequence 1:	NP_001163596.2	Gene:	Octbeta2R / 41549	FlyBaseID:	FBgn0038063	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_741730.1	Gene:	ser-7 / 180565	WormBaseID:	WBGene00004780	Length:	435	Species:	Caenorhabditis elegans

Alignment Length:	421	Identity:	125/421 - (29%)
Similarity:	190/421 - (45%)	Gaps:	86/421 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 AFVMLLIIIAAICGNLLVIISVMRVRKLRVITNYFVVSLAMADIMVAIMAMTFNFSVQVTGRWNF 221
            |..:|.:||....||.||.::|:.||||:...|:.:||||:||..|.::.|.......:..:|..
Worm    45 AIAILAMIIMTTVGNALVCLAVLLVRKLKHPQNFLLVSLAVADFFVGLVVMPLALIDLLFDKWPL 109

  Fly   222 SPFLCDLWNSLDVYFSTASILHLCCISVDRYYAIVKPLKYPISMTKRVVGIMLLNTWISPALLSF 286
            ...:|.::.:.|:...||||::||.||||||..|..||:|....|.:.:.:.:...||..|::|.
Worm   110 GSTMCSVYTTSDLTLCTASIVNLCAISVDRYLVISSPLRYSAKRTTKRIMMYIACVWIIAAIVSI 174

  Fly   287 LPIFI------GWYTTPQHQQFVIQNPTQCSFVVNKYYAVISSSISFWIPCTIMIFTYLAIFREA 345
            ....|      |.|         :.:...|..:.:..|...::.|||:.|..||:...:.|:|.|
Worm   175 SSHIIANLLNDGTY---------VDDTGTCQVIPHFIYQSYATIISFYAPTFIMVILNIKIWRAA 230

  Fly   346 NRQEKQLMMRHGNAMLMHRPSMQPSGEALSGSGSSKTLTLHEVEQEHTPTKDK------HLIKMK 404
            .|...|      :.::.|..|:..|....:||..:|.. |:|.|....|.|::      .|.|::
Worm   231 KRLAAQ------DRLMSHCNSVDASERPRNGSAETKDF-LNEKETIDVPKKERANSTNSRLFKLE 288

  Fly   405 REH------------------------KAARTLGIIMGTFILCWLPFF---------LWYTLSMT 436
            |::                        ||.:|||:||..||:||||||         :|
Worm   289 RKYLHRPSAFFSAAKGPLIRQTEKSECKARKTLGVIMSVFIICWLPFFILAIFKSFGMW------ 347

  Fly   437 CEECQVPDIVVSILFWIGYFNSTLNPLIYAYFNRDFREAFRNTLLCLFCNWWKDRHLPLDIDIRR 501
                 :||.:..:..|:||.|||||||||..:|::||..||..|.|        |...|...:|:
Worm   348 -----IPDWLDLLALWLGYSNSTLNPLIYCKYNKEFRIPFREMLAC--------RCATLQTVMRQ 399

  Fly   502 SSL--RYDQRAK-SVYSESY---LNSTTPSH 526
            .|.  ||....: ...|.||   |:....||
Worm   400 QSFTSRYGPPVRYRTQSSSYRPLLSRRNDSH 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta2R	NP_001163596.2	7tm_4	164..>342	CDD:304433	55/183 (30%)
Octbeta2R	NP_001163596.2	7tm_1	170..465	CDD:278431	100/339 (29%)
ser-7	NP_741730.1	7tmA_5-HT7	42..382	CDD:320452	109/363 (30%)
		TM helix 1	44..68	CDD:320452	9/22 (41%)
		TM helix 2	77..99	CDD:320452	9/21 (43%)
		TM helix 3	115..137	CDD:320452	8/21 (38%)
		TM helix 4	160..176	CDD:320452	4/15 (27%)
		TM helix 5	201..224	CDD:320452	7/22 (32%)
		TM helix 6	315..340	CDD:320452	15/24 (63%)
		TM helix 7	350..375	CDD:320452	13/24 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910