DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Octbeta2R and npr-2

DIOPT Version :9

Sequence 1:	NP_001163596.2	Gene:	Octbeta2R / 41549	FlyBaseID:	FBgn0038063	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_501701.2	Gene:	npr-2 / 177790	WormBaseID:	WBGene00003808	Length:	430	Species:	Caenorhabditis elegans

Alignment Length:	430	Identity:	95/430 - (22%)
Similarity:	163/430 - (37%)	Gaps:	85/430 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   136 HHHQQHNPDEDWLDN------------IVWVFKAFVMLLIIIAAICGNLLVIISVMRVRKLRVIT 188
            |..|..|..|:..|.            .|.|..:.:.|.|.:..|.||..|:...|:.|:|:.:.
Worm    40 HSSQMINETEETCDRYIDKHPDMTNEPTVLVTFSLLYLHIFLLGILGNSAVLYLTMKHRQLQTVQ 104

  Fly   189 NYFVVSLAMADIMVAIMAMTFNFSVQVTGRWNFSPFLC---DLWNSLDVYFSTASILHLCCISVD 250
            |.|:::|..:::::.:.::...|...|..:|.||..:|   .|.....::.||.|   |..|::|
Worm   105 NIFILNLCASNVLMCLTSLPITFITNVYKQWFFSSPVCKLIPLVQGASIFVSTFS---LSAIALD 166

  Fly   251 RYYAIVKPLKYPISMTKRVVGIMLLNTWISPALLSFLPIFIGWYTTPQHQQFVIQNPTQCS---- 311
            ||..:|:|.|..:|....::..:|:  |:...::. :|  .|||...:....:...  .||
Worm   167 RYNLVVRPHKQKLSSRSAMMIALLI--WVISVVVC-MP--YGWYMDVEKLNGLCGE--YCSEHWP 224

  Fly   312 -FVVNKYYAVISSSISFWIPCTIMIFTYLAIF-REANRQEKQLMMRHGNAMLMHRPSMQPSGEAL 374
             ..|.|.|..:.....|..|...|.|.|..|| |...|.|.:|......:.|:         |..
Worm   225 LAEVRKGYTFLVLITQFLFPFATMAFCYYNIFSRLRQRVETKLKKLSERSQLL---------ENS 280

  Fly   375 SGSGSSKTLTLHEVEQEHTPTKDK-HLIKMKREHKAARTLGIIMGTFILCWLP------------ 426
            :..|::..:.....|......::| .|..:.::.:....|..::..|...|||
Worm   281 TTCGTTNHIVSINAEAVQNGLENKQRLAVLAQQRRTTTILSCMVLLFAFTWLPHNVVTLMIEYDG 345

  Fly   427 FFL------------WYTLSMTCEECQVPDIVVSILFWIGYFNSTLNPLIYAYFNRDFREAFRNT 479
            ||.            .|.:|||..       ::|:|      .:..||.:||:.|..|:|....|
Worm   346 FFFHSDETSATSTDHTYIVSMTAH-------LISML------TNVTNPFLYAWLNPMFKEMLIKT 397

  Fly   480 LLCLFCNWWKDRHLPLDIDIRRSSLRYDQRAKSVYSESYL 519
            |.       .....|...||:::|......:.:....|||
Worm   398 LR-------GGSKSPKPADIKQTSFIRMPNSGAPSQSSYL 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta2R	NP_001163596.2	7tm_4	164..>342	CDD:304433	45/185 (24%)
Octbeta2R	NP_001163596.2	7tm_1	170..465	CDD:278431	71/328 (22%)
npr-2	NP_501701.2	7tmA_NPYR-like	70..394	CDD:320331	80/355 (23%)
		TM helix 1	72..96	CDD:320331	6/23 (26%)
		TM helix 2	105..127	CDD:320331	3/21 (14%)
		TM helix 3	143..165	CDD:320331	6/24 (25%)
		TM helix 4	186..202	CDD:320331	3/20 (15%)
		TM helix 5	230..253	CDD:320331	6/22 (27%)
		TM helix 6	314..339	CDD:320331	5/24 (21%)
		TM helix 7	362..387	CDD:320331	10/37 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910