DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Octbeta2R and Htr4

DIOPT Version :9

Sequence 1:	NP_001163596.2	Gene:	Octbeta2R / 41549	FlyBaseID:	FBgn0038063	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_032339.2	Gene:	Htr4 / 15562	MGIID:	109246	Length:	388	Species:	Mus musculus

Alignment Length:	341	Identity:	131/341 - (38%)
Similarity:	182/341 - (53%)	Gaps:	55/341 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 MLLIIIAAICGNLLVIISVMRVRKLRVI-TNYFVVSLAMADIMVAIMAMTFNFSVQVTGRWNFSP 223
            :.::|:.||.|||||:::|.|.|:||.| ||||:||||.||::|:::.|.|.....|...|.:..
Mouse    26 LAVVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWAYGE 90

  Fly   224 FLCDLWNSLDVYFSTASILHLCCISVDRYYAI-VKPLKYPISMTKRVVGIMLLNTWISPALLSFL 287
            ..|.:..||||..:||||.||||||:|||||| .:||.|...||...:.:||...|:.|..:|||
Mouse    91 MFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVLPMFISFL 155

  Fly   288 PIFIGW-----YTTPQHQQFV-IQNPTQCSFVVNKYYAVISSSISFWIPCTIMIFTYLAIFREAN 346
            ||..||     ....:.::|. ..|.|.|.|:|||.||:..|.::|:||..:|:..|..|:..|.
Mouse   156 PIMQGWNNIGIVDVIEKRKFSHNSNSTWCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAK 220

  Fly   347 RQEKQL-MMRHGNAMLMHRPSMQPSGEALSGSGSSKTLTLHEVEQEHTPTKDKHLI-KMKREHKA 409
            ...:|: |::...|....||  ||:                          |:|.. :|:.|.||
Mouse   221 EHAQQIQMLQRAGATSESRP--QPA--------------------------DQHSTHRMRTETKA 257

  Fly   410 ARTLGIIMGTFILCWLPFFLW--------YTLSMTCEECQVPDIVVSILFWIGYFNSTLNPLIYA 466
            |:||.:|||.|..||.|||:.        ||         ||:.|.:...|:||.||.|||.:||
Mouse   258 AKTLCVIMGCFCFCWAPFFVTNIVDPFIDYT---------VPEQVWTAFLWLGYINSGLNPFLYA 313

  Fly   467 YFNRDFREAFRNTLLC 482
            :.|:.||.||...|.|
Mouse   314 FLNKSFRRAFLIILCC 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta2R	NP_001163596.2	7tm_4	164..>342	CDD:304433	82/185 (44%)
Octbeta2R	NP_001163596.2	7tm_1	170..465	CDD:278431	119/312 (38%)
Htr4	NP_032339.2	7tmA_5-HT4	20..323	CDD:320184	127/333 (38%)
		TM helix 1	21..47	CDD:320184	9/20 (45%)
		TM helix 2	55..81	CDD:320184	13/25 (52%)
		TM helix 3	93..123	CDD:320184	20/29 (69%)
		TM helix 4	136..159	CDD:320184	9/22 (41%)
		TM helix 5	189..218	CDD:320184	11/28 (39%)
		TM helix 6	252..282	CDD:320184	15/29 (52%)
		TM helix 7	291..316	CDD:320184	11/24 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005484
OrthoInspector	1	1.000	-	-		otm42843
orthoMCL	1	0.900	-	-		OOG6_107218
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810