Protein Alignment Octbeta2R and Htr2b

DIOPT Version :10

• Sequence 1: NP_001163596.2
• Gene: Octbeta2R / 41549
• FlyBaseID: FBgn0038063
• Length: 630
• Species: Drosophila melanogaster
• Sequence 2: XP_006529209.1
• Gene: Htr2b / 15559
• MGIID: 109323
• Length: 495
• Species: Mus musculus
• Alignment Length: 418
• Identity: 120/418 - (28%)
• Similarity: 186/418 - (44%)
• Gaps: 92/418 - (22%)

  Fly   121 SGLNFNESGAGLSDHHHHQQHNPDEDWLDNIVWVFKAFVMLLIIIAAICGNLLVIISVMRVRKLR 185
            |||..:.....:......|.|        .:.|.  |.::|.:||..|.||:|||::|...::|:
Mouse    31 SGLETDSVAEEMKQTVEGQGH--------TVHWA--ALLILAVIIPTIGGNILVILAVALEKRLQ 85

  Fly   186 VITNYFVVSLAMADIMVAIMAMTFN-FSVQVTGRWNFSPFLCDLWNSLDVYFSTASILHLCCISV 249
            ..||||::|||:||::|.:..|... .::.....|.....||..|..|||.||||||:|||.||:
Mouse    86 YATNYFLMSLAIADLLVGLFVMPIALLTIMFEAIWPLPLALCPAWLFLDVLFSTASIMHLCAISL 150

  Fly   250 DRYYAIVKPLKYPISMTKRVVGIMLLNTWISPALLSFLPIFIGWYTTPQHQ-------------- 300
            |||.||.||::.....::....|.:...|:....:..:|:|      |..|
Mouse   151 DRYIAIKKPIQANQCNSRATAFIKITVVWLISIGMWGMPLF------PYGQNASSGIAIPVPIKG 209

  Fly   301 -QFVIQNP--TQCSFVVNKY--YAVISSSISFWIPCTIMIFTY-LAI-------FREANRQEKQL 352
             :..:.||  ..|....:::  :.|..|..:|:.|.|||:.|| |.|       :...|:..::|
Mouse   210 IETDVINPHNVTCELTKDRFGSFMVFGSLAAFFAPLTIMVVTYFLTIHTLQKKAYLVKNKPPQRL 274

  Fly   353 --------MMRHGN--------AML--MHRPSMQP--SGEALS------GSGSSKTLTLHEVEQE 391
                    .:|..:        |||  .||..:.|  |.|.|.      |..|::|::
Mouse   275 TRWTVPTVFLREDSSFSSPEKVAMLDGSHRDKILPNSSDETLMRRMSSVGKRSAQTIS------- 332

  Fly   392 HTPTKDKHLIKMKREHKAARTLGIIMGTFILCWLPFFLWYTLSMTCEECQVPDI--VVSILFWIG 454
                         .|.:|::.||::...|:|.|.|||:.......|:.|....:  ::.|..|||
Mouse   333 -------------NEQRASKALGVVFFLFLLMWCPFFITNLTLALCDSCNQTTLKTLLEIFVWIG 384

  Fly   455 YFNSTLNPLIYAYFNRDFREAFRNTLLC 482
            |.:|.:|||||..||:.|||||...:.|
Mouse   385 YVSSGVNPLIYTLFNKTFREAFGRYITC 412

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta2R	NP_001163596.2	7tmA_DmOct-betaAR-like	155..476	CDD:320194	111/376 (30%)
		TM helix 1	155..181	CDD:320194	11/25 (44%)
		TM helix 2	188..214	CDD:320194	11/26 (42%)
		TM helix 3	226..256	CDD:320194	20/29 (69%)
		TM helix 4	268..291	CDD:320194	3/22 (14%)
		TM helix 5	315..344	CDD:320194	11/38 (29%)
		TM helix 6	404..434	CDD:320194	10/29 (34%)
		TM helix 7	444..469	CDD:320194	11/26 (42%)
Htr2b	XP_006529209.1	7tm_GPCRs	54..413	CDD:475119	115/387 (30%)
		TM helix 1	56..80	CDD:410628	11/25 (44%)
		TM helix 2	89..111	CDD:410628	10/21 (48%)
		TM helix 3	128..150	CDD:410628	14/21 (67%)
		TM helix 4	173..205	CDD:410628	6/37 (16%)
		TM helix 5	230..253	CDD:410628	8/22 (36%)
		TM helix 6	338..360	CDD:410628	8/21 (38%)
		TM helix 7	374..399	CDD:410628	11/24 (46%)