DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Octbeta2R and Htr2a

DIOPT Version :9

Sequence 1:	NP_001163596.2	Gene:	Octbeta2R / 41549	FlyBaseID:	FBgn0038063	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_766400.1	Gene:	Htr2a / 15558	MGIID:	109521	Length:	471	Species:	Mus musculus

Alignment Length:	387	Identity:	112/387 - (28%)
Similarity:	194/387 - (50%)	Gaps:	39/387 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   141 HNPDEDWLDNIVWVFKAFVMLLIIIAAICGNLLVIISVMRVRKLRVITNYFVVSLAMADIMVAIM 205
            |..:::|        .|.:..::||..|.||:|||::|...:||:..||||::|||:||:::..:
Mouse    70 HLQEKNW--------SALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFL 126

  Fly   206 AMTFNFSVQVTG-RWNFSPFLCDLWNSLDVYFSTASILHLCCISVDRYYAIVKPLKYPISMTKRV 269
            .|..:....:.| ||.....||.:|..|||.||||||:|||.||:|||.||..|:.:....::..
Mouse   127 VMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTK 191

  Fly   270 VGIMLLNTW-ISPALLSFLPIFIGWYTTPQHQQFVIQNPTQCSFVVNKYYAVISSSISFWIPCTI 333
            ..:.::..| ||..:...:|:|     ..|....|.:..: | .:.:..:.:|.|.::|:||.||
Mouse   192 AFLKIIAVWTISVGISMPIPVF-----GLQDDSKVFKEGS-C-LLADDNFVLIGSFVAFFIPLTI 249

  Fly   334 MIFTYLAIFREANRQEKQLMMRHGNAMLMHRPSMQPSGEALSGSGSSKTLTLHEVEQEHTPTKDK 398
            |:.||....:...::....:     :.|..|..:.........|.||:.|....:.:|......:
Mouse   250 MVITYFLTIKSLQKEATLCV-----SDLSTRAKLSSFSFLPQSSLSSEKLFQRSIHREPGSYAGR 309

  Fly   399 HLIK-MKREHKAARTLGIIMGTFILCWLPFFLWYTLSMTCEE-C--QVPDIVVSILFWIGYFNST 459
            ..:: :..|.||.:.|||:...|::.|.|||:...:::.|:| |  .|...::::..||||.:|.
Mouse   310 RTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGALLNVFVWIGYLSSA 374

  Fly   460 LNPLIYAYFNRDFREAFRNTLLCLFCNWWKDRHLPLDIDI---------RRSSLRYDQRAKS 512
            :|||:|..||:.:|.||...:.|.:    |:...||.:.:         :.|.|:..|:..|
Mouse   375 VNPLVYTLFNKTYRSAFSRYIQCQY----KENRKPLQLILVNTIPTLAYKSSQLQVGQKKNS 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta2R	NP_001163596.2	7tm_4	164..>342	CDD:304433	65/179 (36%)
Octbeta2R	NP_001163596.2	7tm_1	170..465	CDD:278431	92/300 (31%)
Htr2a	NP_766400.1	7tm_4	89..>207	CDD:304433	48/117 (41%)
		7tm_1	91..380	CDD:278431	92/300 (31%)
		Agonist binding. /evidence=ECO:0000250\|UniProtKB:P41595	155..160		3/4 (75%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250\|UniProtKB:P41595	172..174		1/1 (100%)
		Agonist binding. /evidence=ECO:0000250\|UniProtKB:P41595	336..340		2/3 (67%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250\|UniProtKB:P41595	376..380		3/3 (100%)
		PDZ-binding. /evidence=ECO:0000250\|UniProtKB:P28223	469..471
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910