Protein Alignment Octbeta2R and Htr1a

DIOPT Version :10

• Sequence 1: NP_001163596.2
• Gene: Octbeta2R / 41549
• FlyBaseID: FBgn0038063
• Length: 630
• Species: Drosophila melanogaster
• Sequence 2: NP_032334.2
• Gene: Htr1a / 15550
• MGIID: 96273
• Length: 421
• Species: Mus musculus
• Alignment Length: 445
• Identity: 136/445 - (30%)
• Similarity: 211/445 - (47%)
• Gaps: 91/445 - (20%)

  Fly   102 LGTATPATHELNATQPFGGSGLNFNESGAGLSDHHHHQQHNPDEDWLDNIVWVFKAFVMLL---I 163
            ||.....|..|   :|||..|   |::|                  |.|:.:.::....||   :
Mouse     6 LGQGNNTTTSL---EPFGTGG---NDTG------------------LSNVTFSYQVITSLLLGTL 46

  Fly   164 IIAAICGNLLVIISVMRVRKLRVITNYFVVSLAMADIMVAIMAMTFNFSVQVTGRWNFSPFLCDL 228
            |..|:.||..|:.::...|.|:.:.||.:.|||:.|:||:::.:......||..:|......|||
Mouse    47 IFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDL 111

  Fly   229 WNSLDVYFSTASILHLCCISVDRYYAIVKPLKYPISMTKRVVGIMLLNTWISPALLSFLPIFIGW 293
            :.:|||...|:||||||.|::|||:||..|:.|....|.|....::..||:...|:| :|..:||
Mouse   112 FIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLIS-IPPMLGW 175

  Fly   294 YTTPQHQQFVIQNPTQCSFVVNKYYAVISSSISFWIPCTIMIFTYLAIFREAN---RQEKQLMMR 355
             .||:.:    .||.:|:...:..|.:.|:..:|:||..:|:..|..|||.|.   |:..:.:.:
Mouse   176 -RTPEDR----SNPNECTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEK 235

  Fly   356 HGNAMLMHRPSMQPSGEALSGSGSS------------------------------KTLTLHEV-- 388
            .|........|..|..::|:|...|                              :.:.:|.|
Mouse   236 KGAGTSFGTSSAPPPKKSLNGQPGSGDCRRSAENRAVGTPCANGAVRQGEDDATLEVIEVHRVGN 300

  Fly   389 EQEHTP----------------------TKDKHLIKMKREHKAARTLGIIMGTFILCWLPFFLWY 431
            .:.|.|                      .:.|..:.:.||.|..:|||||||||||||||||:..
Mouse   301 SKGHLPLPSESGATSYVPACLERKNERTAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVA 365

  Fly   432 TLSMTCE-ECQVPDIVVSILFWIGYFNSTLNPLIYAYFNRDFREAFRNTLLCLFC 485
            .:...|| .|.:|:::.:|:.|:||.||.|||:||||||:||:.||:..:.|.||
Mouse   366 LVLPFCESSCHMPELLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC 420

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta2R	NP_001163596.2	7tmA_DmOct-betaAR-like	155..476	CDD:320194	119/381 (31%)
		TM helix 1	155..181	CDD:320194	7/28 (25%)
		TM helix 2	188..214	CDD:320194	8/25 (32%)
		TM helix 3	226..256	CDD:320194	18/29 (62%)
		TM helix 4	268..291	CDD:320194	6/22 (27%)
		TM helix 5	315..344	CDD:320194	9/28 (32%)
		TM helix 6	404..434	CDD:320194	20/29 (69%)
		TM helix 7	444..469	CDD:320194	13/24 (54%)
Htr1a	NP_032334.2	7tmA_5-HT1A_vertebrates	37..411	CDD:320453	119/379 (31%)
		TM helix 1	38..64	CDD:320453	7/25 (28%)
		TM helix 2	71..97	CDD:320453	8/25 (32%)
		TM helix 3	109..139	CDD:320453	18/29 (62%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	133..135		1/1 (100%)
		TM helix 4	151..173	CDD:320453	6/22 (27%)
		TM helix 5	192..221	CDD:320453	9/28 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	237..268		6/30 (20%)
		TM helix 6	338..368	CDD:320453	20/29 (69%)
		TM helix 7	379..404	CDD:320453	13/24 (54%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	396..400		2/3 (67%)