Protein Alignment Octbeta2R and Htr1a

DIOPT Version :9

• Sequence 1: NP_001163596.2
• Gene: Octbeta2R / 41549
• FlyBaseID: FBgn0038063
• Length: 630
• Species: Drosophila melanogaster
• Sequence 2: NP_032334.2
• Gene: Htr1a / 15550
• MGIID: 96273
• Length: 421
• Species: Mus musculus
• Alignment Length: 445
• Identity: 136/445 - (30%)
• Similarity: 211/445 - (47%)
• Gaps: 91/445 - (20%)

  Fly   102 LGTATPATHELNATQPFGGSGLNFNESGAGLSDHHHHQQHNPDEDWLDNIVWVFKAFVMLL---I 163
            ||.....|..|   :|||..|   |::|                  |.|:.:.::....||   :
Mouse     6 LGQGNNTTTSL---EPFGTGG---NDTG------------------LSNVTFSYQVITSLLLGTL 46

  Fly   164 IIAAICGNLLVIISVMRVRKLRVITNYFVVSLAMADIMVAIMAMTFNFSVQVTGRWNFSPFLCDL 228
            |..|:.||..|:.::...|.|:.:.||.:.|||:.|:||:::.:......||..:|......|||
Mouse    47 IFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDL 111

  Fly   229 WNSLDVYFSTASILHLCCISVDRYYAIVKPLKYPISMTKRVVGIMLLNTWISPALLSFLPIFIGW 293
            :.:|||...|:||||||.|::|||:||..|:.|....|.|....::..||:...|:| :|..:||
Mouse   112 FIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLIS-IPPMLGW 175

  Fly   294 YTTPQHQQFVIQNPTQCSFVVNKYYAVISSSISFWIPCTIMIFTYLAIFREAN---RQEKQLMMR 355
             .||:.:    .||.:|:...:..|.:.|:..:|:||..:|:..|..|||.|.   |:..:.:.:
Mouse   176 -RTPEDR----SNPNECTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEK 235

  Fly   356 HGNAMLMHRPSMQPSGEALSGSGSS------------------------------KTLTLHEV-- 388
            .|........|..|..::|:|...|                              :.:.:|.|
Mouse   236 KGAGTSFGTSSAPPPKKSLNGQPGSGDCRRSAENRAVGTPCANGAVRQGEDDATLEVIEVHRVGN 300

  Fly   389 EQEHTP----------------------TKDKHLIKMKREHKAARTLGIIMGTFILCWLPFFLWY 431
            .:.|.|                      .:.|..:.:.||.|..:|||||||||||||||||:..
Mouse   301 SKGHLPLPSESGATSYVPACLERKNERTAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVA 365

  Fly   432 TLSMTCE-ECQVPDIVVSILFWIGYFNSTLNPLIYAYFNRDFREAFRNTLLCLFC 485
            .:...|| .|.:|:::.:|:.|:||.||.|||:||||||:||:.||:..:.|.||
Mouse   366 LVLPFCESSCHMPELLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC 420

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta2R	NP_001163596.2	7tm_4	164..>342	CDD:304433	60/177 (34%)
		7tm_1	170..465	CDD:278431	107/352 (30%)
Htr1a	NP_032334.2	7tm_4	48..>169	CDD:304433	44/121 (36%)
		7tm_1	53..400	CDD:278431	107/352 (30%)
		Agonist binding. /evidence=ECO:0000250	112..121		3/8 (38%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250	133..135		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	237..268		6/30 (20%)
		Agonist binding. /evidence=ECO:0000250	358..362		3/3 (100%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250	396..400		2/3 (67%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910