DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Octbeta2R and ADRB2

DIOPT Version :9

Sequence 1:	NP_001163596.2	Gene:	Octbeta2R / 41549	FlyBaseID:	FBgn0038063	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_000015.2	Gene:	ADRB2 / 154	HGNCID:	286	Length:	413	Species:	Homo sapiens

Alignment Length:	405	Identity:	147/405 - (36%)
Similarity:	206/405 - (50%)	Gaps:	55/405 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 QPFGGSGLNFNESGAGLSDHHHHQQHNPDEDWLDNIVWVFKAFVMLLIIIAAICGNLLVIISVMR 180
            ||..||......:|:...||...|:.  ||.|:     |....||.||::|.:.||:|||.::.:
Human     3 QPGNGSAFLLAPNGSHAPDHDVTQER--DEVWV-----VGMGIVMSLIVLAIVFGNVLVITAIAK 60

  Fly   181 VRKLRVITNYFVVSLAMADIMVAIMAMTFNFSVQVTGRWNFSPFLCDLWNSLDVYFSTASILHLC 245
            ..:|:.:||||:.|||.||:::.:..:.|..:..:...|.|..|.|:.|.|:||...||||..||
Human    61 FERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLC 125

  Fly   246 CISVDRYYAIVKPLKYPISMTKRVVGIMLLNTWISPALLSFLPIFIGWYTTPQHQQFV--IQNPT 308
            .|:||||:||..|.||...:||....:::|..||...|.|||||.:.||.. .||:.:  ..|.|
Human   126 VIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRA-THQEAINCYANET 189

  Fly   309 QCSFVVNKYYAVISSSISFWIPCTIMIFTYLAIFREANRQEKQLMMRHGNAMLMHRPSMQPSGEA 373
            .|.|..|:.||:.||.:||::|..||:|.|..:|:||.||.:::....|...:.:...::..|..
Human   190 CCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRT 254

  Fly   374 LSGSGSSKTLTLHEVEQEHTPTKDKHLIKMKREHKAARTLGIIMGTFILCWLPFFLWYTLSMTCE 438
            ..|...|....|                   :||||.:|||||||||.|||||||: ..:....:
Human   255 GHGLRRSSKFCL-------------------KEHKALKTLGIIMGTFTLCWLPFFI-VNIVHVIQ 299

  Fly   439 ECQVPDIVVSILFWIGYFNSTLNPLIYAYFNRDFREAFRNTLLCLFCNWWKDRHLPLDIDIRRSS 503
            :..:...|..:|.||||.||..|||||.. :.|||.||:. ||||                ||||
Human   300 DNLIRKEVYILLNWIGYVNSGFNPLIYCR-SPDFRIAFQE-LLCL----------------RRSS 346

  Fly   504 LRYDQRAKSVYSESY 518
            |:       .|...|
Human   347 LK-------AYGNGY 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta2R	NP_001163596.2	7tm_4	164..>342	CDD:304433	72/179 (40%)
Octbeta2R	NP_001163596.2	7tm_1	170..465	CDD:278431	112/296 (38%)
ADRB2	NP_000015.2	7tmA_Beta2_AR	34..336	CDD:341355	123/323 (38%)
		TM helix 1	36..60	CDD:341355	10/23 (43%)
		TM helix 2	69..91	CDD:341355	9/21 (43%)
		TM helix 3	107..129	CDD:341355	11/21 (52%)
		TM helix 4	152..168	CDD:341355	6/15 (40%)
		TM helix 5	197..220	CDD:341355	10/22 (45%)
		TM helix 6	272..294	CDD:341355	16/22 (73%)
		TM helix 7	305..330	CDD:341355	13/25 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	392..413
		PDZ-binding	410..413
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H30948
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40768
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24248
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4701
SonicParanoid	1	1.000	-	-		X822
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	6.040