DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Octbeta2R and ADRA1D

DIOPT Version :9

Sequence 1:	NP_001163596.2	Gene:	Octbeta2R / 41549	FlyBaseID:	FBgn0038063	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_000669.1	Gene:	ADRA1D / 146	HGNCID:	280	Length:	572	Species:	Homo sapiens

Alignment Length:	575	Identity:	164/575 - (28%)
Similarity:	250/575 - (43%)	Gaps:	95/575 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 SSASNSSTGGIALPLGTATPATHELNATQPFGGSGLNFNESGAGLSDHHHHQQHNP-------DE 145
            |||..||.||.....|.|.|:........| ||:|......|||..:.:......|       |.
Human    18 SSAGGSSAGGGGGSAGGAAPSEGPAVGGVP-GGAGGGGGVVGAGSGEDNRSSAGEPGSAGAGGDV 81

  Fly   146 DWLDNI-----------VWVFKAFVMLLIIIAAICGNLLVIISVMRVRKLRVITNYFVVSLAMAD 199
            :....:           |.||.|    ..|:.|:.||||||:||...|.|:.:||||:|:||:||
Human    82 NGTAAVGGLVVSAQGVGVGVFLA----AFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVAD 142

  Fly   200 IMVAIMAMTFNFSVQVTGRWNFSPFLCDLWNSLDVYFSTASILHLCCISVDRYYAIVKPLKYPIS 264
            ::::...:.|:.:::|.|.|.|....||:|.::||...|||||.||.||||||..:...||||..
Human   143 LLLSATVLPFSATMEVLGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAI 207

  Fly   265 MTKRVVGIMLLNTWISPALLSFLPIFIGW-YTTPQHQQFVIQNPTQCSFVVNKYYAVISSSISFW 328
            ||:|....:|...|:...::|..|: :|| ...|..::|       |.......|||.||..||:
Human   208 MTERKAAAILALLWVVALVVSVGPL-LGWKEPVPPDERF-------CGITEEAGYAVFSSVCSFY 264

  Fly   329 IPCTIMIFTYLAIF---REANRQ-EKQLMMRHGNA----MLMHRPSMQPSGEALSGSGSSKTLTL 385
            :|..:::..|..::   |...|. |..:....|.|    :.:|........:...|..|:|..|.
Human   265 LPMAVIVVMYCRVYVVARSTTRSLEAGVKRERGKASEVVLRIHCRGAATGADGAHGMRSAKGHTF 329

  Fly   386 HEVEQEHTPTKDKHLIKMKREHKAARTLGIIMGTFILCWLPFFLWYTLSMTCEECQVPDIVVSIL 450
            ..       :....|:|..||.|||:||.|::|.|:|||.|||....|.....:.:..:.|..::
Human   330 RS-------SLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVI 387

  Fly   451 FWIGYFNSTLNPLIYAYFNRDFREAFRNTLLC-------------LFCNWWKDRHLPLDIDIRRS 502
            ||:|||||.:|||||...:|:|:.||...|.|             ::.:.|:.....|..|...|
Human   388 FWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRRRPLWRVYGHHWRASTSGLRQDCAPS 452

  Fly   503 SLRYDQRAKSVYSESYLNSTTP------------SHRRQSQMVDNLXYRDEALLTPIAQQQQRLA 555
            |  .|....:..:.:.|....|            :.||:...    .:|:..||.|..:...:|.
Human   453 S--GDAPPGAPLALTALPDPDPEPPGTPEMQAPVASRRKPPS----AFREWRLLGPFRRPTTQLR 511

  Fly   556 AGGSRLGGQLAAAAKDGRESKDAKDTGKDAGKGKSNVDCLAGDDVQEIQIEIPME 610
            |..|.|..::.|                 .|..::...|....:|:.:.:.:|.|
Human   512 AKVSSLSHKIRA-----------------GGAQRAEAACAQRSEVEAVSLGVPHE 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta2R	NP_001163596.2	7tm_4	164..>342	CDD:304433	69/178 (39%)
Octbeta2R	NP_001163596.2	7tm_1	170..465	CDD:278431	107/303 (35%)
ADRA1D	NP_000669.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..77		18/59 (31%)
		7tmA_alpha1D_AR	97..413	CDD:320450	117/334 (35%)
		TM helix 1	98..124	CDD:320450	14/29 (48%)
		TM helix 2	131..157	CDD:320450	10/25 (40%)
		TM helix 3	169..199	CDD:320450	18/29 (62%)
		TM helix 4	211..234	CDD:320450	5/23 (22%)
		TM helix 5	251..280	CDD:320450	9/28 (32%)
		TM helix 6	341..371	CDD:320450	16/29 (55%)
		TM helix 7	381..406	CDD:320450	13/24 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	444..488		7/45 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910