DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Octbeta2R and Drd5

DIOPT Version :9

Sequence 1:	NP_001163596.2	Gene:	Octbeta2R / 41549	FlyBaseID:	FBgn0038063	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_038531.1	Gene:	Drd5 / 13492	MGIID:	94927	Length:	478	Species:	Mus musculus

Alignment Length:	452	Identity:	143/452 - (31%)
Similarity:	207/452 - (45%)	Gaps:	113/452 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 ASNSSTGGIALPLGTATPATHELNATQPFGGSGLNFNESGAGLSDHHHHQQHNPDEDWLDNIVWV 154
            |...:.||.|.|||.|...|                    |||
Mouse    22 AQVDAPGGSAAPLGPAQVVT--------------------AGL---------------------- 44

  Fly   155 FKAFVMLLIIIAAICGNLLVIISVMRVRKLRV-ITNYFVVSLAMADIMVAIMAMTFNFSVQVTGR 218
                 :.|:|:..:.||:||..:::|.|.||. :||.|:||||::|:.||::.|.:....:|.|.
Mouse    45 -----LTLLIVWTLLGNVLVCAAIVRSRHLRAKMTNIFIVSLAVSDLFVALLVMPWKAVAEVAGY 104

  Fly   219 WNFSPFLCDLWNSLDVYFSTASILHLCCISVDRYYAIVKPLKYPISMTKRVVGIMLLNTWISPAL 283
            |.|..| ||:|.:.|:..||||||:||.||||||:||.:|.:|...||:||..:|:...|....|
Mouse   105 WPFGAF-CDIWVAFDIMCSTASILNLCIISVDRYWAISRPFRYERKMTQRVALVMVALAWTLSIL 168

  Fly   284 LSFLPIFIGWY---------------TTPQHQQFVIQNPTQ-CSFVVNKYYAVISSSISFWIPCT 332
            :||:|:.:.|:               .||..:.:.:...|: |...:|:.||:.||.|||:||..
Mouse   169 ISFIPVQLNWHRDKAGSQGREGLLSNETPWEEGWELDGRTENCDSSLNRTYAISSSLISFYIPVA 233

  Fly   333 IMIFTYLAIFREANRQEKQLMMRHGNAMLMHRPSMQPSGEALSGSGSSKTLTLHEVEQEHTPTKD 397
            |||.||..|:|.|..|.:::......|  .|..|.:..|..                 |..|:.
Mouse   234 IMIVTYTRIYRIAQVQIRRISSLERAA--EHAQSCRSRGAC-----------------EPDPSL- 278

  Fly   398 KHLIKMKREHKAARTLGIIMGTFILCWLPFFLWYTLSMTCEE-----------CQVPDIVVSILF 451
              ...:|:|.|..:||.:|||.|:.||||||:...:...|..           | |.:....|..
Mouse   279 --RASIKKETKVFKTLSVIMGVFVCCWLPFFILNCMVPFCSSGDAQGPRTGFPC-VSETTFDIFV 340

  Fly   452 WIGYFNSTLNPLIYAYFNRDFREAFRNTLLCLFCNWWKDRHL----PLD-IDIRRSSLRYDQ 508
            |.|:.||:|||:||| ||.|||:.|...|.|        .||    |:. ::|....:.|:|
Mouse   341 WFGWANSSLNPIIYA-FNADFRKVFAQLLGC--------SHLCFRTPVQTVNISNELISYNQ 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta2R	NP_001163596.2	7tm_4	164..>342	CDD:304433	77/194 (40%)
Octbeta2R	NP_001163596.2	7tm_1	170..465	CDD:278431	112/322 (35%)
Drd5	NP_038531.1	7tm_1	55..354	CDD:278431	112/322 (35%)
		7tm_4	<121..>173	CDD:304433	27/51 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	416..446
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24248
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.970