DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Octbeta2R and Adrb2

DIOPT Version :9

Sequence 1:	NP_001163596.2	Gene:	Octbeta2R / 41549	FlyBaseID:	FBgn0038063	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_031446.2	Gene:	Adrb2 / 11555	MGIID:	87938	Length:	418	Species:	Mus musculus

Alignment Length:	397	Identity:	141/397 - (35%)
Similarity:	206/397 - (51%)	Gaps:	55/397 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 SGAGLSDHHHHQQHNPDEDWLDNIVWVFKAFVMLLIIIAAICGNLLVIISVMRVRKLRVITNYFV 192
            :|:...||...|:.  ||.|:     |..|.:|.:|::|.:.||:|||.::.:..:|:.:||||:
Mouse    15 NGSRAPDHDVTQER--DEAWV-----VGMAILMSVIVLAIVFGNVLVITAIAKFERLQTVTNYFI 72

  Fly   193 VSLAMADIMVAIMAMTFNFSVQVTGRWNFSPFLCDLWNSLDVYFSTASILHLCCISVDRYYAIVK 257
            :|||.||:::.:..:.|..|..:...|||..|.|:.|.|:||...||||..||.|:||||.||..
Mouse    73 ISLACADLVMGLAVVPFGASHILMKMWNFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYVAITS 137

  Fly   258 PLKYPISMTKRVVGIMLLNTWISPALLSFLPIFIGWYTTPQHQQFV--IQNPTQCSFVVNKYYAV 320
            |.||...:||....:::|..||...|.|||||.:.||.. .|::.:  ....|.|.|..|:.||:
Mouse   138 PFKYQSLLTKNKARVVILMVWIVSGLTSFLPIQMHWYRA-THKKAIDCYTEETCCDFFTNQAYAI 201

  Fly   321 ISSSISFWIPCTIMIFTYLAIFREANRQEKQLMMRHGNAMLMHRPSMQPSGEALSGSGSSKTLTL 385
            .||.:||::|..:|:|.|..:|:.|.||.:::....|.....:...::..|.  ||.|..::
Mouse   202 ASSIVSFYVPLVVMVFVYSRVFQVAKRQLQKIDKSEGRFHAQNLSQVEQDGR--SGHGLRRS--- 261

  Fly   386 HEVEQEHTPTKDKHLIKMKREHKAARTLGIIMGTFILCWLPFFLWYTLSMTCEECQVPDIVVSIL 450
                       .|..:|   ||||.:|||||||||.|||||||: ..:.....:..:|..|..:|
Mouse   262 -----------SKFCLK---EHKALKTLGIIMGTFTLCWLPFFI-VNIVHVIRDNLIPKEVYILL 311

  Fly   451 FWIGYFNSTLNPLIYAYFNRDFREAFRNTLLCLFCNWWKDRHLPLDIDIRRSSLRYDQRAKSVYS 515
            .|:||.||..|||||.. :.|||.||:. ||||                ||||       ...|.
Mouse   312 NWLGYVNSAFNPLIYCR-SPDFRIAFQE-LLCL----------------RRSS-------SKTYG 351

  Fly   516 ESYLNST 522
            ..|.:::
Mouse   352 NGYSSNS 358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta2R	NP_001163596.2	7tm_4	164..>342	CDD:304433	71/179 (40%)
Octbeta2R	NP_001163596.2	7tm_1	170..465	CDD:278431	112/296 (38%)
Adrb2	NP_031446.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23		2/7 (29%)
		7tm_4	48..340	CDD:304433	119/314 (38%)
		7tm_1	50..326	CDD:278431	112/296 (38%)
		PDZ-binding	415..418
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H30948
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8780
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24248
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4701
SonicParanoid	1	1.000	-	-		X822
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.040