DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Octbeta2R and Adra2b

DIOPT Version :9

Sequence 1:	NP_001163596.2	Gene:	Octbeta2R / 41549	FlyBaseID:	FBgn0038063	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_033763.3	Gene:	Adra2b / 11552	MGIID:	87935	Length:	448	Species:	Mus musculus

Alignment Length:	440	Identity:	125/440 - (28%)
Similarity:	184/440 - (41%)	Gaps:	120/440 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 AFVMLLIIIAAICGNLLVIISVMRVRKLRVITNYFVVSLAMADIMVAIMAMTFNFSVQVTGRWNF 221
            |..:..:|:..|.||.|||::|:..|.||...|.|:||||.|||:||.:.:.|:.:.::.|.|.|
Mouse    16 ASAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYF 80

  Fly   222 SPFLCDLWNSLDVYFSTASILHLCCISVDRYYAIVKPLKYPISMTKRVVGIMLLNTWISPALLSF 286
            ....|:::.:|||.|.|:||:|||.||:|||:|:.:.|:|....|.|.:..::|..|:..|::|.
Mouse    81 WRAWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAAVISL 145

  Fly   287 LPIFIGWYTTPQHQQFVIQNPTQCSFVVNKYYAVISSSISFWIPCTIMIFTYLAIFREANRQE-K 350
            .|:.......|:....     .||......:|.:.||..||:.||.|||..||.|:..|.|.. :
Mouse   146 PPLIYKGDQRPEPHGL-----PQCELNQEAWYILASSIGSFFAPCLIMILVYLRIYVIAKRSHCR 205

  Fly   351 QLMMRHGNAMLMHRPSMQPSGEALSGSGSSKTLTL-----------------HEVEQEHTP---- 394
            .|..:.|:.   ...|.:|...|.....|:|..||                 .|.|:..||
Mouse   206 GLGAKRGSG---EGESKKPHPAAGGVPASAKVPTLVSPLSSVGEANGHPKPPREKEEGETPEDPE 267

  Fly   395 -------------------------TKDK------------------------------------ 398
                                     |.:|
Mouse   268 ARALPPNWSALPRSVQDQKKGTSGATAEKGAEEDEEEVEECEPQTLPASPASVFNPPLQQPQTSR 332

  Fly   399 ------------------------HLIKMKREHKAARTLGIIMGTFILCWLPFFLWYTLSMTC-E 438
                                    ...::.||.:....|.:::|.|::||.|||..|:|...| :
Mouse   333 VLATLRGQVLLSKNVGVASGQWWRRRTQLSREKRFTFVLAVVIGVFVVCWFPFFFSYSLGAICPQ 397

  Fly   439 ECQVPDIVVSILFWIGYFNSTLNPLIYAYFNRDFREAFRNTLLCLFCNWW 488
            .|:||..:....|||||.||:|||:||..||:|||.|||..|    |..|
Mouse   398 HCKVPHGLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAFRRIL----CRQW 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta2R	NP_001163596.2	7tm_4	164..>342	CDD:304433	67/177 (38%)
Octbeta2R	NP_001163596.2	7tm_1	170..465	CDD:278431	109/402 (27%)
Adra2b	NP_033763.3	7tmA_alpha2B_AR	7..435	CDD:320444	119/426 (28%)
		TM helix 1	14..40	CDD:320444	9/23 (39%)
		TM helix 2	47..73	CDD:320444	12/25 (48%)
		TM helix 3	85..115	CDD:320444	17/29 (59%)
		TM helix 4	127..150	CDD:320444	6/22 (27%)
		TM helix 5	169..198	CDD:320444	13/28 (46%)
		PRK12323	<209..354	CDD:237057	14/147 (10%)
		TM helix 6	362..392	CDD:320444	11/29 (38%)
		TM helix 7	403..428	CDD:320444	12/24 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910