DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Octbeta2R and Adora1

DIOPT Version :9

Sequence 1:	NP_001163596.2	Gene:	Octbeta2R / 41549	FlyBaseID:	FBgn0038063	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_001008533.1	Gene:	Adora1 / 11539	MGIID:	99401	Length:	326	Species:	Mus musculus

Alignment Length:	370	Identity:	94/370 - (25%)
Similarity:	158/370 - (42%)	Gaps:	94/370 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 VMLLIIIAAICGNLLVIISVMRVRKLRVITNYFVVSLAMADIMVAIMAMTFNFSVQVTGRWNFSP 223
            :.:||.:.::.||:|||.:|...:.||..|..|:||||:||  ||:.|:....::.:    |..|
Mouse    15 IEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVAD--VAVGALVIPLAILI----NIGP 73

  Fly   224 FLCDLWNSLDVYFST-------------ASILHLCCISVDRYYAIVKPLKYPISMTKRVVGIMLL 275
                     ..||.|             :|||.|..|:||||..:..||:|...:|:|...:.:.
Mouse    74 ---------QTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIA 129

  Fly   276 NTWISPALLSFLPIFIGWYTTPQHQQFVIQNPT------QCSF--VVNKYYAVISSSISFWI--P 330
            ..||...::...|:| ||....:.:|..|.|.:      :|.|  |::..| ::..:...|:  |
Mouse   130 GCWILSLVVGLTPMF-GWNNLSEVEQAWIANGSVGEPVIKCEFEKVISMEY-MVYFNFFVWVLPP 192

  Fly   331 CTIMIFTYLAIFREANRQEKQLMMRHGNAMLMHRPSMQPSGEALSGSGSSKTLTLHEVEQEHTPT 395
            ..:|:..||.:|....:|             :::.....||:.....|
Mouse   193 LLLMVLIYLEVFYLIRKQ-------------LNKKVSASSGDPQKYYG----------------- 227

  Fly   396 KDKHLIKMKREHKAARTLGIIMGTFILCWLPFFLWYTLSMTCEECQVPDIVVSILFWIGYFNSTL 460
                     :|.|.|::|.:|:..|.|.|||..:...:::.|..||.|.|::.|..::.:.||.:
Mouse   228 ---------KELKIAKSLALILFLFALSWLPLHILNCITLFCPTCQKPSILIYIAIFLTHGNSAM 283

  Fly   461 NPLIYAYFNRDFREAFRNTLLCLFCNWWKDRHL------PLDIDI 499
            ||::||:....||..|...        |.| |.      |::.||
Mouse   284 NPIVYAFRIHKFRVTFLKI--------WND-HFRCQPKPPIEEDI 319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta2R	NP_001163596.2	7tm_4	164..>342	CDD:304433	56/200 (28%)
Octbeta2R	NP_001163596.2	7tm_1	170..465	CDD:278431	81/317 (26%)
Adora1	NP_001008533.1	7tmA_Adenosine_R_A1	10..299	CDD:341323	87/339 (26%)
		TM helix 1	10..37	CDD:341323	8/21 (38%)
		TM helix 2	44..71	CDD:341323	11/32 (34%)
		TM helix 3	80..110	CDD:341323	9/29 (31%)
		TM helix 4	124..142	CDD:341323	2/17 (12%)
		TM helix 5	177..207	CDD:341323	7/30 (23%)
		TM helix 6	227..257	CDD:341323	11/55 (20%)
		TM helix 7	267..292	CDD:341323	8/24 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910