DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Octbeta2R and adra1d

DIOPT Version :9

Sequence 1:	NP_001163596.2	Gene:	Octbeta2R / 41549	FlyBaseID:	FBgn0038063	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	XP_002935531.2	Gene:	adra1d / 100495969	XenbaseID:	XB-GENE-6050827	Length:	500	Species:	Xenopus tropicalis

Alignment Length:	476	Identity:	136/476 - (28%)
Similarity:	230/476 - (48%)	Gaps:	67/476 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 VMLLIIIAAICGNLLVIISVMRVRKLRVITNYFVVSLAMADIMVAIMAMTFNFSVQVTGRWNFSP 223
            |:.:.|:.||.||::||:||...|:|:.:||||:|:||:||::::...:.|:.:::|.|.|.|..
Frog    48 VLAVFILFAIVGNIMVILSVACNRQLQTVTNYFIVNLAIADLLLSTTVLPFSATLEVLGFWAFGR 112

  Fly   224 FLCDLWNSLDVYFSTASILHLCCISVDRYYAIVKPLKYPISMTKRVVGIMLLNTWISPALLSFLP 288
            ..||:|.::||...||||:.||.||:|||..:...||||..||::...::|:..|:|..::|..|
Frog   113 VFCDIWAAVDVLCCTASIMSLCVISIDRYVGVKYSLKYPTIMTEKKAVVILILLWLSSMVISIGP 177

  Fly   289 IFIGWYTTPQHQQFVIQNPTQCSFVVNKYYAVISSSISFWIPCTIMIFTYLAIFREANRQEKQLM 353
            : :||...|.      .:.::||......||:.||..||::|..:::..|..::..|.|..|.|
Frog   178 L-LGWKEPPP------PDDSKCSITEEPGYALFSSLFSFYLPLLVILVMYFRVYIVARRTTKSL- 234

  Fly   354 MRHGNAMLMHRPSMQPSGEALSGSGSSKTLTLH--EVEQEHTPTKDKH------------LIKMK 404
              ..........||:            ..|.:|  .|.:|.:.:...|            |:|..
Frog   235 --EAGVKKERNKSME------------VVLRIHCRSVLEESSSSTRNHKGHTFRSSLSVRLLKFS 285

  Fly   405 REHKAARTLGIIMGTFILCWLPFFLWYTLSMTCEECQVPDIVVSILFWIGYFNSTLNPLIYAYFN 469
            ||.|||:||.|::|.||||||||||...|.......:..|.|..::||:|||||.:||:||...:
Frog   286 REKKAAKTLAIVVGVFILCWLPFFLILPLGSFFPALKPTDSVFKVIFWLGYFNSCVNPIIYPCSS 350

  Fly   470 RDFREAFRNTLLCLFCNWWKDRHLPL----DIDIRRSSLRYDQRAKSVYSESY--LNST---TPS 525
            ::|:.||...|.|. |   :.|..|:    |...|.|.....:.:...:..::  :||:   .|.
Frog   351 KEFKRAFIRILKCQ-C---RRRRRPIWRVYDHQWRTSMTSSGRGSDGEHHPNFTPINSSFIFNPG 411

  Fly   526 HRRQSQMVDNLXYRDEALLTPIAQQQQRLAAGGSRLGGQLAAAAKDGRESKDAKDTGKDAGKGKS 590
            :...:....|. :|....::|..:...:|                  :|..::......:|..:|
Frog   412 NHGIAGKRKNTDFRRWKFISPFQRPSSQL------------------KEKMNSLSHKIRSGSNRS 458

  Fly   591 NVDCLAGDDVQEIQIEIPMEY 611
            |.......:|:.|.:.:..::
Frog   459 NSSAAYKSEVESISMAVSNDF 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta2R	NP_001163596.2	7tm_4	164..>342	CDD:304433	65/177 (37%)
Octbeta2R	NP_001163596.2	7tm_1	170..465	CDD:278431	106/308 (34%)
adra1d	XP_002935531.2	7tmA_alpha1D_AR	43..357	CDD:320450	113/330 (34%)
		TM helix 1	44..70	CDD:320450	10/21 (48%)
		TM helix 2	77..103	CDD:320450	10/25 (40%)
		TM helix 3	115..145	CDD:320450	16/29 (55%)
		TM helix 4	157..180	CDD:320450	5/23 (22%)
		TM helix 5	197..226	CDD:320450	8/28 (29%)
		TM helix 6	285..315	CDD:320450	19/29 (66%)
		TM helix 7	325..350	CDD:320450	13/24 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910