DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Octbeta2R and drd5

DIOPT Version :9

Sequence 1:	NP_001163596.2	Gene:	Octbeta2R / 41549	FlyBaseID:	FBgn0038063	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	XP_004911296.1	Gene:	drd5 / 100495174	XenbaseID:	XB-GENE-992519	Length:	455	Species:	Xenopus tropicalis

Alignment Length:	361	Identity:	128/361 - (35%)
Similarity:	191/361 - (52%)	Gaps:	36/361 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 VMLLIIIAAICGNLLVIISVMRVRKLR-VITNYFVVSLAMADIMVAIMAMTFNFSVQVTGRWNFS 222
            ::||:|...:.||:||..:|||.|.|| .:||.|:||||::|::||::.|.:....:|.|.|.|.
Frog    47 LLLLLIFWTLFGNILVCTAVMRFRHLRNRVTNIFIVSLAVSDLLVALLVMPWKAVAEVAGHWPFG 111

  Fly   223 PFLCDLWNSLDVYFSTASILHLCCISVDRYYAIVKPLKYPISMTKRVVGIMLLNTWISPALLSFL 287
            .| ||:|.:.|:..||||||:||.||||||:||..|.:|...||:||..:|:...|....|:||:
Frog   112 AF-CDIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTQRVALLMISAAWALSVLISFI 175

  Fly   288 PIFIGWYTTPQHQQFVIQNPT-QCSFVVNKYYAVISSSISFWIPCTIMIFTYLAIFREANRQEKQ 351
            |:.:.|:.:......:....| .|...:|:.||:.||.|||:||..|||.||..|:|.|..|.::
Frog   176 PVQLSWHKSETDDHLLSNQSTGNCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQIQIRR 240

  Fly   352 LMMRHGNAMLMHRPSMQPSGEALSGSGSSKTLTLHEVEQEHTPTKDKHLIKMKREHKAARTLGII 416
            :            .:::.:.|......|::....|......|        .:|:|.|..:||.||
Frog   241 I------------STLERAAEHAQSCRSNRVDCRHHQSSLKT--------SIKKETKVLKTLSII 285

  Fly   417 MGTFILCWLPFFLWYTLSMTCEECQ---------VPDIVVSILFWIGYFNSTLNPLIYAYFNRDF 472
            ||.|:.||||||:...:...|:...         |.:....|..|.|:.||:|||:||| ||.||
Frog   286 MGVFVCCWLPFFILNCMVPFCDRSSGHPQAGLPCVSETTFDIFVWFGWANSSLNPIIYA-FNADF 349

  Fly   473 REAFRNTLLCLFCNWWKDRHLPLDIDIRRSSLRYDQ 508
            |:.|.:   .|.|..|........::|....:.|:|
Frog   350 RKVFSS---LLGCGHWCSTTPVETVNISNELISYNQ 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta2R	NP_001163596.2	7tm_4	164..>342	CDD:304433	77/179 (43%)
Octbeta2R	NP_001163596.2	7tm_1	170..465	CDD:278431	110/305 (36%)
drd5	XP_004911296.1	7tm_GPCRs	42..353	CDD:391938	121/327 (37%)
		TM helix 1	44..68	CDD:341315	8/20 (40%)
		TM helix 2	78..100	CDD:341315	10/21 (48%)
		TM helix 3	115..137	CDD:341315	12/21 (57%)
		TM helix 4	160..176	CDD:341315	5/15 (33%)
		TM helix 5	205..228	CDD:341315	13/22 (59%)
		TM helix 6	276..301	CDD:341315	14/24 (58%)
		TM helix 7	322..347	CDD:341315	12/25 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24248
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100