DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Octbeta2R and htr7

DIOPT Version :9

Sequence 1:	NP_001163596.2	Gene:	Octbeta2R / 41549	FlyBaseID:	FBgn0038063	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	XP_031762460.1	Gene:	htr7 / 100494876	XenbaseID:	XB-GENE-1013674	Length:	440	Species:	Xenopus tropicalis

Alignment Length:	345	Identity:	130/345 - (37%)
Similarity:	186/345 - (53%)	Gaps:	42/345 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 VMLLIIIAAICGNLLVIISVMRVRKLRVITNYFVVSLAMADIMVAIMAMTFNFSVQVT----GRW 219
            ::.||.:..|.||.||:|||..|:|||..:||.:||||:||:.|||..|.|   |.||    |.|
Frog    84 ILSLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAIAVMPF---VSVTDLIGGEW 145

  Fly   220 NFSPFLCDLWNSLDVYFSTASILHLCCISVDRYYAIVKPLKYPISMTKRVVGIMLLNTWISPALL 284
            .|....|:::.::||...||||:.||.||:|||..|.:||.||:....|.:..|:|..|:..|.:
Frog   146 IFGHVFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGRCMAKMILCVWLLSASI 210

  Fly   285 SFLPIFIGWYTTPQHQQFVIQNPTQCSFVVNKYYAVISSSISFWIPCTIMIFTYLAIFREANRQE 349
            :..|:| ||...       :.:...|....:..|.:.|::::|:||.::|:|.|..||:.|.|..
Frog   211 TLPPLF-GWAQN-------VNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYRIFKAAKRSA 267

  Fly   350 KQLMMRHGNAMLMHR----PSMQPSGEALSGSGSSKTLTLHEVEQEHTPTKD------KHLIKMK 404
            .:           |:    |..:.|...:|.:|:.||   |:..:|.|....      |::...|
Frog   268 AK-----------HKFTGLPRPEESEGMISANGNVKT---HKESEECTNLSKLLRNDRKNISIFK 318

  Fly   405 REHKAARTLGIIMGTFILCWLPFFLWYTL-SMTC-EECQ-VPDIVVSILFWIGYFNSTLNPLIYA 466
            ||.|||.|||||:|.|.:|||||||..|. ...| .||. :|..:.....|:||.||.:||.|||
Frog   319 REQKAATTLGIIVGAFTICWLPFFLLSTARPFICGTECSCIPLWLERTFLWLGYANSLINPFIYA 383

  Fly   467 YFNRDFREAFRNTLLCLFCN 486
            :||||.|..:||.|.|.:.|
Frog   384 FFNRDLRTTYRNLLQCRYRN 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta2R	NP_001163596.2	7tm_4	164..>342	CDD:304433	68/181 (38%)
Octbeta2R	NP_001163596.2	7tm_1	170..465	CDD:278431	114/311 (37%)
htr7	XP_031762460.1	7tmA_5-HT7	80..393	CDD:320452	125/333 (38%)
		TM helix 1	81..105	CDD:320452	10/20 (50%)
		TM helix 2	114..136	CDD:320452	13/24 (54%)
		TM helix 3	153..175	CDD:320452	9/21 (43%)
		TM helix 4	198..214	CDD:320452	4/15 (27%)
		TM helix 5	234..257	CDD:320452	7/22 (32%)
		TM helix 6	324..346	CDD:320452	15/21 (71%)
		TM helix 7	361..386	CDD:320452	10/24 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910