DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Octbeta2R and htr4

DIOPT Version :9

Sequence 1:	NP_001163596.2	Gene:	Octbeta2R / 41549	FlyBaseID:	FBgn0038063	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	XP_002939852.1	Gene:	htr4 / 100493952	XenbaseID:	XB-GENE-993770	Length:	386	Species:	Xenopus tropicalis

Alignment Length:	353	Identity:	136/353 - (38%)
Similarity:	188/353 - (53%)	Gaps:	53/353 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 IIIAAICGNLLVIISVMRVRKLRVI-TNYFVVSLAMADIMVAIMAMTFNFSVQVTGRWNFSPFLC 226
            :|:..|.|||||:::|.|.|:||.| ||||:||||.||::|:::.|.|.....|..:|.:....|
Frog    28 VILMTILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQEKWIYGEMFC 92

  Fly   227 DLWNSLDVYFSTASILHLCCISVDRYYAI-VKPLKYPISMTKRVVGIMLLNTWISPALLSFLPIF 290
            .:..||||..:|||||||||||:|||||| .:||.|...||...:.:||...||.|..:|||||.
Frog    93 LVRTSLDVLLTTASILHLCCISLDRYYAICCQPLVYRNKMTPLRITLMLSGCWIIPTFISFLPIM 157

  Fly   291 IGWYT--------TPQHQQFVIQNPTQCSFVVNKYYAVISSSISFWIPCTIMIFTYLAIFREANR 347
            .||.:        |.::.:  ..|.|.|.|:|||.||:..|.::|:||..:|:..|..|:..|..
Frog   158 QGWNSIGILDLIETRKYNK--SSNSTNCIFMVNKPYAITCSVVAFYIPFFLMVLAYYRIYITARE 220

  Fly   348 QEKQL-MMRHGNAMLMHRPSMQPSGEALSGSGSSKTLTLHEVEQEHTPTKDKHLIKMKREHKAAR 411
            ..:|: :::...|...||                     |:...:||    .|  :||.|.|||:
Frog   221 HARQIGVLQRAGAPADHR---------------------HQHPDQHT----TH--RMKTETKAAK 258

  Fly   412 TLGIIMGTFILCWLPFFLWYTLSMTCEECQVPDIVVSILFWIGYFNSTLNPLIYAYFNRDFREAF 476
            ||.||||.|.|||.|||:...:.... ...||..:.:...|:||.||.|||.:||:.|:.||.||
Frog   259 TLCIIMGCFCLCWAPFFITNVVDPFI-NYSVPVELWTAFLWLGYINSGLNPFLYAFLNKSFRRAF 322

  Fly   477 RNTLLCLFCNWWKDRHLPLDIDIRRSSL 504
               |:.|.|.         |...||.|:
Frog   323 ---LIILCCG---------DEKYRRPSI 338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta2R	NP_001163596.2	7tm_4	164..>342	CDD:304433	83/187 (44%)
Octbeta2R	NP_001163596.2	7tm_1	170..465	CDD:278431	120/305 (39%)
htr4	XP_002939852.1	7tmA_5-HT4	19..322	CDD:320184	127/323 (39%)
		TM helix 1	20..46	CDD:320184	8/17 (47%)
		TM helix 2	54..80	CDD:320184	13/25 (52%)
		TM helix 3	92..122	CDD:320184	21/29 (72%)
		TM helix 4	135..158	CDD:320184	10/22 (45%)
		TM helix 5	188..217	CDD:320184	11/28 (39%)
		TM helix 6	251..281	CDD:320184	18/29 (62%)
		TM helix 7	290..315	CDD:320184	10/24 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D328277at33208
OrthoFinder	1	1.000	-	-		FOG0005484
OrthoInspector	1	1.000	-	-		mtm14086
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010