DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Octbeta2R and trhr

DIOPT Version :9

Sequence 1:	NP_001163596.2	Gene:	Octbeta2R / 41549	FlyBaseID:	FBgn0038063	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	XP_002938958.3	Gene:	trhr / 100492507	XenbaseID:	XB-GENE-992328	Length:	397	Species:	Xenopus tropicalis

Alignment Length:	423	Identity:	102/423 - (24%)
Similarity:	170/423 - (40%)	Gaps:	94/423 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 VFKAFVMLLIIIAAICGNLLVIISVMRVRKLRVITNYFVVSLAMADIMVAIMAMTFNFSVQVTGR 218
            |...|:::||....|.||::|::.|::.:.:|..||.::||||:||::|.:.|...|.:..|.|.
Frog    26 VVTVFLVVLICGLGIVGNIMVVLVVLQTKHMRTPTNCYLVSLAIADLIVLVAAGLPNITESVYGS 90

  Fly   219 WNFSPFLCDLWNSLDVYFSTASILHLCCISVDRYYAIVKPLK----YPISMTKRVVGIMLLNTWI 279
            |.:....|.....|......||...:...:|:||.||..|:|    ..||..|:::    :..|.
Frog    91 WVYGYIGCLCITYLQYLGINASSCSITAFTVERYLAICHPIKAQFLCTISRAKKII----VFVWA 151

  Fly   280 SPALLSFLPIFIGWYTTPQHQQFVIQNPTQCSF-VVNKYYA---VISSSISFWIPCTIMIFTYLA 340
            ..:|...:..|:....|..::...:.|   |.: |...:|:   :|...|.:.:|.|:....|..
Frog   152 FTSLYCLMWFFLLDLNTTIYKDATVVN---CGYRVPRSFYSPIYLIDFGIFYAVPMTLATVLYGL 213

  Fly   341 IFREANRQEKQLMMRHGNAMLMHRPSMQPSGEALSGSGSSKTLTLHEVEQEHTPTKDK------- 398
            |.|                :|...|......|      :|||.. ::|..::.....|
Frog   214 IAR----------------ILFLNPIPSDPKE------NSKTWK-NDVTHQNKAFNSKMSSRCSN 255

  Fly   399 HLIKMKREHKAARTLGIIMGTFILCWLPF--------FL-------WYTLSMTCEECQVPDIVVS 448
            :.|..:|:  ..:.|.:::..|...|:|:        ||       |:.|  .|..|.
Frog   256 NTIASRRQ--VTKMLAVVVILFAFLWMPYRTLVVVNSFLSRPYLQTWFVL--FCRICI------- 309

  Fly   449 ILFWIGYFNSTLNPLIYAYFNRDFREAFRNTLLCLFCNWWKDR-HLPLDIDIRRSSLRYDQRAKS 512
                  |.||.:||:||...::.||.|||.     .|...|.| ..|.:..:   :|.|     |
Frog   310 ------YLNSAINPVIYNLMSQKFRAAFRK-----LCKCKKKRSEKPANYGV---ALNY-----S 355

  Fly   513 VYSESYLNSTTPSHRRQSQMVDNLXYRDEALLT 545
            |..|| .|..:|.|  .|..:::: ..|..|.|
Frog   356 VIKES-SNGGSPDH--FSTELEDITVTDTYLST 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta2R	NP_001163596.2	7tm_4	164..>342	CDD:304433	47/185 (25%)
Octbeta2R	NP_001163596.2	7tm_1	170..465	CDD:278431	73/324 (23%)
trhr	XP_002938958.3	7tmA_TRH-R	26..331	CDD:320126	82/351 (23%)
		TM helix 1	28..52	CDD:320126	8/23 (35%)
		TM helix 2	61..84	CDD:320126	10/22 (45%)
		TM helix 3	99..121	CDD:320126	3/21 (14%)
		TM helix 4	144..160	CDD:320126	2/19 (11%)
		TM helix 5	189..212	CDD:320126	4/22 (18%)
		TM helix 6	265..287	CDD:320126	4/21 (19%)
		TM helix 7	299..324	CDD:320126	11/39 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910