Protein Alignment Octbeta2R and chrm1

DIOPT Version :9

• Sequence 1: NP_001163596.2
• Gene: Octbeta2R / 41549
• FlyBaseID: FBgn0038063
• Length: 630
• Species: Drosophila melanogaster
• Sequence 2: XP_004913717.1
• Gene: chrm1 / 100490434
• XenbaseID: XB-GENE-22061118
• Length: 521
• Species: Xenopus tropicalis
• Alignment Length: 548
• Identity: 138/548 - (25%)
• Similarity: 202/548 - (36%)
• Gaps: 216/548 - (39%)

  Fly   104 TATPATHELNATQ---PFGGSGLNFNESGAGLSDHHHHQQHNPDEDWLDNIVWVFKAFVMLLII- 164
            |.||.|.  |||:   |.||                             :.||.    |:|::|
 Frog    24 TVTPLTS--NATEEYDPLGG-----------------------------HAVWE----VVLIVIT 53

  Fly   165 -----IAAICGNLLVIISVMRVRKLRVITNYFVVSLAMADIMVAIMAMTFNFSVQVTGRWNFSPF 224
                 :..:.||:||:::......|:.:.|||::|||.|||::..::|....:..|.|||...|.
 Frog    54 TGILSLVTVIGNVLVLLAFKVNSDLKTVNNYFLLSLACADIIIGALSMNLYTTYIVMGRWALGPV 118

  Fly   225 LCDLWNSLDVYFSTASILHLCCISVDRYYAIVKPLKYPISMTKRVVGIMLLNTWISPALLSFL-- 287
            .||||.:||...|.||:::|..||.|||::|.:||.|....|.|...||:...|    .:||:
 Frog   119 SCDLWLALDYVASNASVMNLLIISFDRYFSITRPLTYRAKRTPRRAAIMIGMAW----FISFVLW 179

  Fly   288 -PIFIGWYTTPQHQQFVI----QNPTQCSFVVNKYYAVISSSI--------SFWIPCTIMIFTYL 339
             |..|.|       |:::    ...|.|      |....|..|        :|::|.||||..|.
 Frog   180 APAIIFW-------QYIVGERTVEATDC------YIQFFSQPIITFGTAIAAFYLPVTIMIILYW 231

  Fly   340 AIFREANRQEKQL------------------MMRHGNA--------------------------- 359
            .::||...:.|:|                  .:|.|::
 Frog   232 RVYRETENRSKELAGLQGSGTDHTSHPLALGSVRSGSSSGAGESERLSRGQRTVPRAKQGCCFPR 296

  Fly   360 MLMHRPSMQ-----------------PSGEALSGS------------------------------ 377
            .|...||::                 .|.::||.|
 Frog   297 QLTSNPSLRSYPEHRSNGSCNTMEDAASADSLSSSSEAEDRPYEMKNICSAVIRLPMVSSVVGTP 361

  Fly   378 ----GSSKTLTLHEVEQE---------------------------------HTPTKDKHLIKMKR 405
                |||.||...::|.|                                 |...|...|||
 Frog   362 KGSRGSSDTLGRGDIEAETNGGKSEVTRKTSRAQVTALPSTIIRAKSEKNHHGKRKSNSLIK--- 423

  Fly   406 EHKAARTLGIIMGTFILCWLPFFLWYTLSMTCEECQVPDIVVSILFWIGYFNSTLNPLIYAYFNR 470
            |.|||:||..|:..|||.|.|:.:...:|..|.:| ||..:..:.:|:.|.|||:||:.||..||
 Frog   424 EKKAAKTLSAILLAFILTWTPYNIMVLVSTFCPDC-VPKKLWELGYWLCYVNSTVNPMCYALCNR 487

  Fly   471 DFREAFRNTLLCLFCNW----WKDRHLP 494
            .||..|:   :.|.|.|    |:....|
 Frog   488 SFRRTFK---MLLLCRWDKRKWRAHKHP 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta2R	NP_001163596.2	7tm_4	164..>342	CDD:304433	63/198 (32%)
		7tm_1	170..465	CDD:278431	111/438 (25%)
chrm1	XP_004913717.1	7tmA_mAChR_M1	48..493	CDD:341356	119/465 (26%)
		TM helix 1	49..75	CDD:341356	6/25 (24%)
		TM helix 2	82..108	CDD:341356	10/25 (40%)
		TM helix 3	120..150	CDD:341356	15/29 (52%)
		TM helix 4	162..185	CDD:341356	7/26 (27%)
		TM helix 5	207..236	CDD:341356	8/28 (29%)
		TM helix 6	422..452	CDD:341356	14/32 (44%)
		TM helix 7	461..486	CDD:341356	9/24 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910