DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Octbeta2R and ackr4

DIOPT Version :9

Sequence 1:	NP_001163596.2	Gene:	Octbeta2R / 41549	FlyBaseID:	FBgn0038063	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	XP_002937785.1	Gene:	ackr4 / 100487207	XenbaseID:	XB-GENE-6258927	Length:	356	Species:	Xenopus tropicalis

Alignment Length:	437	Identity:	83/437 - (18%)
Similarity:	178/437 - (40%)	Gaps:	112/437 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 ELNATQ-PFGGSGLNFNESGAGLSDHHHHQQHNPDEDWLDNIVWVFKAFVMLLIIIAAICGNLLV 174
            ::|.|| |   :..|::|.|....|:.:::: ..::..:.....:|......:..:..:.||.||
Frog     4 KINTTQRP---TTENYDEYGDTTFDYSNYEE-LCEKKGVRQFAQIFLPAFYAVAFVIGVAGNSLV 64

  Fly   175 IISVMRVRKLRVITNYFVVSLAMADIMVAIMAMTFNFSVQVTGRWNFSPFLCDLWNSLDVYFSTA 239
            :......:|::..|:.::::||:||::: :..:.| ::......|.|..|:|.:.:::.....::
Frog    65 VAIYAYYKKMKSKTDVYLLNLAVADLLL-LFTLPF-WATDAAVGWQFGIFMCKITSAMYTINFSS 127

  Fly   240 SILHLCCISVDRYYAIVK-PLKYPISMTKRVVGIMLLNTWISPALLSFLPIFIGWYTTPQHQQFV 303
            .:..|.|||:|||:|:.| |...||   :::..:..|..|.:..|||...::..  |..:|
Frog   128 GMQFLACISLDRYFAVTKAPNPQPI---RKICWVTCLFVWSTSMLLSIPDLYFS--TVKEH---- 183

  Fly   304 IQNPTQCSFVVNK--------YYAVISSSISFWIPCTIMIFTYLAIFREANRQEKQLMMRHGNAM 360
             .|...|..|..|        ...::.....|.:|..:|:|.|.::.:                :
Frog   184 -NNKHACLPVYPKDTIKQTTVLIQILEIVFCFLLPFLVMLFCYASMAK----------------I 231

  Fly   361 LMHRPSMQPSGEALSGSGSSKTLTLHEVEQEHTPTKDKHLIKMKREHKAARTLGIIMGTFILCWL 425
            ::..|:::.|                                     ::.:.|..::|.|::..|
Frog   232 VLQTPNIKRS-------------------------------------RSLKVLLAVVGVFLITQL 259

  Fly   426 PFFL---W------YTLSMTCEECQVPDIVVSILFWIGYFNSTLNPLIYAYFNRDFREAFRNTLL 481
            |:.:   |      |.|..:|...:..||::.:...:..|:|.|||::||:....|:.....
Frog   260 PYNVIKFWRAIDIIYALITSCSMSRTIDIMIQVTESLALFHSCLNPILYAFMGTTFKSYISK--- 321

  Fly   482 CLFCNWWKDRHLPLDIDIRRSSLRYDQRAKS-----VYSESYLNSTT 523
                           |..|..:|| .||.:|     ::||:::..|:
Frog   322 ---------------IAKRYGALR-RQRIQSTEEYAMHSENHVEETS 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta2R	NP_001163596.2	7tm_4	164..>342	CDD:304433	43/186 (23%)
Octbeta2R	NP_001163596.2	7tm_1	170..465	CDD:278431	61/312 (20%)
ackr4	XP_002937785.1	7tmA_ACKR4_CCR11	44..319	CDD:320304	65/339 (19%)
		TM helix 1	44..71	CDD:320304	5/26 (19%)
		TM helix 2	78..103	CDD:320304	6/26 (23%)
		TM helix 3	114..144	CDD:320304	9/29 (31%)
		TM helix 4	154..176	CDD:320304	5/21 (24%)
		TM helix 5	202..231	CDD:320304	5/44 (11%)
		TM helix 6	238..268	CDD:320304	6/66 (9%)
		TM helix 7	287..312	CDD:320304	9/24 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910