Protein Alignment Octbeta2R and hrh4.b2

DIOPT Version :10

• Sequence 1: NP_001163596.2
• Gene: Octbeta2R / 41549
• FlyBaseID: FBgn0038063
• Length: 630
• Species: Drosophila melanogaster
• Sequence 2: XP_031760447.1
• Gene: hrh4.b2 / 100485915
• XenbaseID: XB-GENE-22168371
• Length: 390
• Species: Xenopus tropicalis
• Alignment Length: 397
• Identity: 94/397 - (23%)
• Similarity: 181/397 - (45%)
• Gaps: 57/397 - (14%)

  Fly   121 SGLNFNESGAGLSDHHHHQQHNPDEDWLDNIVWVFKAFVMLLIIIAAICGNLLVIISVMRVRKLR 185
            ||:|.....||.:           ..:.|.:..:..|.:.|||:: .:.||.|||::....::||
 Frog    10 SGINLTLDTAGST-----------TQFSDAVNILIIALISLLILL-TVGGNTLVILAFFVEKRLR 62

  Fly   186 VITNYFVVSLAMADIMVAIMAMTFNFSVQVTGRWNFSPFLCDLWNSLDVYFSTASILHLCCISVD 250
            ..:|:|:::|::||.::...|:.......:||:|....|||.||..:|....|||..::..||.|
 Frog    63 NQSNFFLLNLSIADFILGTFAIPLYVPYLLTGKWLLGKFLCKLWLIVDYTMCTASAFNVALISWD 127

  Fly   251 RYYAIVKPLKYPISMTK--RVVGIMLLNTWISPALLSFL---PIFIGWYTTPQHQQFVIQNPTQC 310
            |:.::.:.:.|.....:  |.| |.:...||    ||||   |..|.|...|..:: :.:|....
 Frog   128 RFLSVTQAVLYRSQQNRPCRTV-IKMAAVWI----LSFLLYGPAIIFWDFVPSTEE-IPENICVA 186

  Fly   311 SFVVNKYYAVISSSISFWIPCTIMIFTYLAIFREANRQEKQLMMRHGNAMLMHRPSMQPSGEA-L 374
            .|....||.:.:|:..|.:|...:.|..|:|:....::.::.|.   |::.:  |..:...|| |
 Frog   187 GFYYTWYYLLTASAFDFVLPLISISFFNLSIYCNIKKRSRRKMQ---NSISL--PPQKSRKEAKL 246

  Fly   375 SGSGSSKTLTLHEVE--------------------------QEHTPTKDKHLIKMKREHKAARTL 413
            ....::.||...:::                          .:.:..::..:..:.|:.|.|::|
 Frog   247 CTIATNITLQSPQIDIQKKSFRRRINISCNQCFGIKSSSHNNKRSDRENNQVSDLSRDKKVAKSL 311

  Fly   414 GIIMGTFILCWLPFFLWYTLSMTCEECQVPDIVVSILFWIGYFNSTLNPLIYAYFNRDFREAFRN 478
            .:::..|.:||.|:....::...|....:......|.||:.:.||.:||:||...::.|::||.|
 Frog   312 SVLVCIFAICWAPYSFLMSIRAACHGYCIHIYWYDITFWLLWTNSAINPIIYPLCHKGFQKAFLN 376

  Fly   479 TL--LCL 483
            .:  :|:
 Frog   377 IVKYVCM 383

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta2R	NP_001163596.2	7tmA_DmOct-betaAR-like	155..476	CDD:320194	84/352 (24%)
		TM helix 1	155..181	CDD:320194	9/25 (36%)
		TM helix 2	188..214	CDD:320194	6/25 (24%)
		TM helix 3	226..256	CDD:320194	11/29 (38%)
		TM helix 4	268..291	CDD:320194	10/25 (40%)
		TM helix 5	315..344	CDD:320194	8/28 (29%)
		TM helix 6	404..434	CDD:320194	8/29 (28%)
		TM helix 7	444..469	CDD:320194	9/24 (38%)
hrh4.b2	XP_031760447.1	7tmA_Histamine_H3R_H4R	44..374	CDD:320176	80/340 (24%)
		TM helix 2	65..92	CDD:320176	6/26 (23%)
		TM helix 3	103..133	CDD:320176	11/29 (38%)
		TM helix 4	148..166	CDD:320176	8/22 (36%)
		TM helix 5	191..221	CDD:320176	8/29 (28%)
		TM helix 6	302..332	CDD:320176	8/29 (28%)
		TM helix 7	342..367	CDD:320176	9/24 (38%)