DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Octbeta2R and gpr27

DIOPT Version :9

Sequence 1:	NP_001163596.2	Gene:	Octbeta2R / 41549	FlyBaseID:	FBgn0038063	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	XP_012817202.1	Gene:	gpr27 / 100485839	XenbaseID:	XB-GENE-978905	Length:	370	Species:	Xenopus tropicalis

Alignment Length:	360	Identity:	76/360 - (21%)
Similarity:	146/360 - (40%)	Gaps:	30/360 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 VWVFKAFVMLLIIIAAICGNLLVIISVMRVRKLRVITNYFVVSLAMADIMVAIMAMTFNF-SVQV 215
            |.|.|...:.:|...::.||||.....::.:.|.....|.::.|.:.|::.:::...... |:..
Frog    21 VSVAKLASLGIIACVSLAGNLLFAFIALKDKNLHRAPYYLMLDLCVGDLIRSLLCFPLVLKSISS 85

  Fly   216 TGRWNFSPFLCDLWNSLDVYFSTASILHLCCISVDRYYAIVKPLKYPISMTKRVVGIMLLNTWIS 280
            ..:|.:|...|.:.....|.....:...|..||:.||.||.....|...||.....|::...||.
Frog    86 GSQWTYSKRSCRIMAFGAVLLCFHAAFMLLSISLTRYMAIAHHRFYCKRMTGWACAIVISMAWIL 150

  Fly   281 PALLSFLPIF-IGWYTTPQHQQFVIQNPTQCSFVVNKYYAVISS-----SISFWIPCTIMIFTYL 339
            ...::..|:| :|.|.       .|:...||:| .::|.....|     .::|.:..|..|:..|
Frog   151 STAMALPPVFEVGTYK-------FIREEDQCTF-EHRYVKANDSLGFLLMLAFIVGATHFIYMKL 207

  Fly   340 AIFREANRQEK--QLMMRHGNAMLMHRPSM--QPSGEALSGSGSSKT----LTLHEVEQEHTPTK 396
            ..|...:|:.|  ||..........|.|..  |.:...::|.|...|    :.:.:..|.|.
Frog   208 LFFIYDHRKMKPAQLTPAISQNWSFHGPGAAGQAAANWIAGFGRGPTPPTLVGMRQSTQGHI--- 269

  Fly   397 DKHLI---KMKREHKAARTLGIIMGTFILCWLPFFLWYTLSMTCEECQVPDIVVSILFWIGYFNS 458
             |.|:   :.|:|.:..:...:|...|::.|.|:.|...|.:..:...:|...::...|:.:..:
Frog   270 -KRLVVLEEFKQEKRLCKMFYVITFLFLVFWAPYLLACYLRVFLKASSLPQGYLTTAVWLTFAQA 333

  Fly   459 TLNPLIYAYFNRDFREAFRNTLLCLFCNWWKDRHL 493
            .:||::....|::.|.:.|..:.|......:|.::
Frog   334 GVNPIVCLLLNKEVRMSLRAYIPCKSTQTQRDPYM 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta2R	NP_001163596.2	7tm_4	164..>342	CDD:304433	40/184 (22%)
Octbeta2R	NP_001163596.2	7tm_1	170..465	CDD:278431	67/312 (21%)
gpr27	XP_012817202.1	7tmA_SREB-like	25..351	CDD:320134	71/337 (21%)
		TM helix 1	25..50	CDD:320134	6/24 (25%)
		TM helix 2	57..82	CDD:320134	3/24 (13%)
		TM helix 3	96..126	CDD:320134	8/29 (28%)
		TM helix 4	140..160	CDD:320134	4/19 (21%)
		TM helix 5	181..210	CDD:320134	5/28 (18%)
		TM helix 6	279..309	CDD:320134	7/29 (24%)
		TM helix 7	319..344	CDD:320134	3/24 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910