DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Octbeta2R and tacr1

DIOPT Version :9

Sequence 1:	NP_001163596.2	Gene:	Octbeta2R / 41549	FlyBaseID:	FBgn0038063	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_001106489.1	Gene:	tacr1 / 100127678	XenbaseID:	XB-GENE-5835469	Length:	407	Species:	Xenopus tropicalis

Alignment Length:	376	Identity:	82/376 - (21%)
Similarity:	160/376 - (42%)	Gaps:	69/376 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 LIIIAAICGNLLVIISVMRVRKLRVITNYFVVSLAMADIMVAIMAMTFNFSVQVTGRWNFSPFLC 226
            :|:|.::.||::|:..::..:::|.:||||:|:||.|:..::......||:..:...|.:....|
Frog    41 IIVIVSVVGNIIVMWIILAHKRMRTVTNYFLVNLAFAEASMSAFNTVINFTYAIHNHWYYGLIYC 105

  Fly   227 DLWNSLDVYFSTASILHLCCISVDRYYAIVKPLKYPISMTKRVVGIMLLNTWISPALLSFLPIFI 291
            ...|...:....:||..:..|::|||.||:.|||..:|.|...:.|.::  |.....|:|..
Frog   106 KFHNFFPISAVFSSIYSMTAIALDRYMAIIHPLKPRLSATATRIVIAVI--WGFAFALAFPQ--- 165

  Fly   292 GWYT----TPQHQQFVIQNPTQCSFVVNKYYAVISSSISFWIPCTIMIFTYLAIFREANRQEKQL 352
            |::.    ||......::.|...:....|.|.|:...:.:::|..::..:|..|
Frog   166 GYFATVEPTPDRVVCYMEWPESENRKFEKVYQVLLFGLIYFLPLLVIGCSYTFI----------- 219

  Fly   353 MMRHGNAMLMHRPSMQPSGEALSGSGSSKTLTLHEVEQEHTPTKDKHLIKMKREHKAARTLGIIM 417
                                       ..||...|:..:   :.|::..::..:.|..:.:.:::
Frog   220 ---------------------------GMTLWASEIPGD---SSDRYHEQVVAKRKVVKMMIVVV 254

  Fly   418 GTFILCWLPFFLWYTLSMTCEECQVPD--------IVVSILFWIGYFNSTLNPLIYAYFNRDFRE 474
            .||.:||||:.:::.|.:.     :||        :.:.|: |:|..::..||:||...|..||.
Frog   255 CTFAICWLPYHIYFLLQLF-----LPDESQKFYQQLYLGIM-WLGMSSTMYNPIIYCCLNDRFRI 313

  Fly   475 AFRNTLLCLFCNWWKDRHLPLDIDIRRSSLRYDQRAKSVYSESYLNSTTPS 525
            .|::..     .|....|......:...|.||.|...|:|..|.:.:|..|
Frog   314 GFKHVF-----RWCPFIHAGEYEGLEMKSTRYLQTQSSMYKISRIETTVSS 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta2R	NP_001163596.2	7tm_4	164..>342	CDD:304433	44/181 (24%)
Octbeta2R	NP_001163596.2	7tm_1	170..465	CDD:278431	63/306 (21%)
tacr1	NP_001106489.1	7tmA_NK1R	33..315	CDD:320668	70/325 (22%)
		TM helix 1	34..60	CDD:320668	5/18 (28%)
		TM helix 2	67..93	CDD:320668	10/25 (40%)
		TM helix 3	105..135	CDD:320668	9/29 (31%)
		TM helix 4	146..167	CDD:320668	4/25 (16%)
		TM helix 5	193..222	CDD:320668	6/66 (9%)
		TM helix 6	241..271	CDD:320668	7/29 (24%)
		TM helix 7	283..308	CDD:320668	7/25 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910