DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Octbeta2R and gpr84

DIOPT Version :9

Sequence 1:	NP_001163596.2	Gene:	Octbeta2R / 41549	FlyBaseID:	FBgn0038063	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	XP_021332416.1	Gene:	gpr84 / 100126017	ZFINID:	ZDB-GENE-070928-33	Length:	410	Species:	Danio rerio

Alignment Length:	387	Identity:	85/387 - (21%)
Similarity:	160/387 - (41%)	Gaps:	87/387 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 FKAFVMLL---IIIAAICGNLLVIISVMRVRKLRVITNYFVVSLAMADIMVAIMAMTFNFSVQVT 216
            ::.|.:||   :.|....||:|.:::.:....||...|..:|:||.||::...:....:....:.
Zfish    31 YRYFGVLLGSAVTIVGTIGNILTVLAFVTDANLRTRFNVLIVNLAFADLLYCTILQPVSVDSYLH 95

  Fly   217 GRWNFSPFLCDLWNSLDVYFSTASILHLCCISVDRYYAIVKPLK--YPISMTKRVVGIMLLNTWI 279
            ..|......|.::..|....::.||:.||.|::.||..:.....  ..:.:::|.|..:|:::|:
Zfish    96 LHWRGGATWCRMFGLLLFLSNSVSIITLCLIAMSRYLVVAHRTSSCARLLLSQRGVAALLISSWV 160

  Fly   280 SPALLSFLPIFIGWYTTPQHQQFVIQNPTQCSF--VVNKYYAVISSSISFWIPCTIMIFTYLAIF 342
            . .|.||.|::..:...||        ...|||  ...:.|..:...:.|::....:...|..|:
Zfish   161 L-GLASFAPLWPVYVFAPQ--------VCTCSFHRTKGRPYTTVLLFLYFFLGLGFVGLFYFLIY 216

  Fly   343 REANRQEKQLMMRHGNAMLMHRPSMQPS----GEAL-----SG--SGSSKTLTLH-----EVEQE 391
            |:.:...|        |.|.:|||.:.|    .||.     ||  :|:|.|.:..     .|.::
Zfish   217 RKVSVAAK--------AFLKYRPSRRSSKRKQAEAEGTTDDSGISAGASTTQSCEISSDGAVAEQ 273

  Fly   392 H--------TPTKDKHLIKMKREHKAARTLG-----IIMGT------------------------ 419
            |        |.|::      ..:|.::.|..     :|..|
Zfish   274 HGKQAQEGQTTTQN------ATQHASSETTSKASPVVIQNTPAAANSGEDNEFKRVTRMCFTVFL 332

  Fly   420 -FILCWLPFFLWYTLSMTCEECQVPDIVVSILFWIGYFNSTLNPLIYAYFNRDFREAFRNTL 480
             |:.|:.||.|   |::..::.:.|.::..|...:.:.||.:|||:||..||.|.:|:::.|
Zfish   333 CFVGCFAPFLL---LNVADKKNRAPQVIHMICANLTWLNSCINPLLYAAMNRQFNQAYKDLL 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta2R	NP_001163596.2	7tm_4	164..>342	CDD:304433	38/181 (21%)
Octbeta2R	NP_001163596.2	7tm_1	170..465	CDD:278431	74/352 (21%)
gpr84	XP_021332416.1	7tmA_GPR84-like	33..387	CDD:320338	83/379 (22%)
		TM helix 1	34..60	CDD:320338	7/25 (28%)
		TM helix 2	67..90	CDD:320338	6/22 (27%)
		TM helix 3	105..135	CDD:320338	9/29 (31%)
		TM helix 4	151..169	CDD:320338	6/18 (33%)
		TM helix 5	189..214	CDD:320338	3/24 (13%)
		TM helix 6	318..348	CDD:320338	6/32 (19%)
		TM helix 7	355..380	CDD:320338	8/24 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910