| Sequence 1: | NP_001163596.2 | Gene: | Octbeta2R / 41549 | FlyBaseID: | FBgn0038063 | Length: | 630 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001090831.1 | Gene: | cxcr4 / 100038176 | XenbaseID: | XB-GENE-489917 | Length: | 358 | Species: | Xenopus tropicalis |
| Alignment Length: | 445 | Identity: | 95/445 - (21%) |
|---|---|---|---|
| Similarity: | 172/445 - (38%) | Gaps: | 113/445 - (25%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 95 TGGIALPLGTATPATHELNATQPFGGSGLNFNESGAGLSDHHHHQQHNPDEDWLDNIVWVFKAFV 159
Fly 160 MLLIIIAAICGNLLVIISVMRVRKLRVITNYFVVSLAMADIMVAIMAMTFNFSVQVTGRWNFSPF 224
Fly 225 LCDLWNSLDVYFST---ASILHLCCISVDRYYAIVKPLKYPISMTKRVVGIMLLNTWISPALLSF 286
Fly 287 LPIFIGWYTTPQHQQFVIQN--PTQCSFVVNKYYAVISSSISFWIPCTIMIFTYLAIFREANRQE 349
Fly 350 KQLMMRHGNAMLMHRPSMQPSGEALSGSGSSKTLTLHEVEQEHTPTKDKHLIKMKREHKAARTLG 414
Fly 415 IIMGTFILCWLPFFLWYT------LSMTCEECQVPDIV---VSILFWIGYFNSTLNPLIYAYFNR 470
Fly 471 DFREAFRNTLLCLFCNWWKDRHLPLDIDIRRSSLRY--DQRA--KSVYSESYLNS 521 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| Octbeta2R | NP_001163596.2 | 7tm_4 | 164..>342 | CDD:304433 | 45/182 (25%) |
| 7tm_1 | 170..465 | CDD:278431 | 67/308 (22%) | ||
| cxcr4 | NP_001090831.1 | Important for chemokine binding and signaling. /evidence=ECO:0000250 | 1..25 | 6/26 (23%) | |
| CXCR4_N | 10..42 | CDD:371902 | 6/42 (14%) | ||
| 7tmA_CXCR4 | 43..320 | CDD:341334 | 73/335 (22%) | ||
| TM helix 1 | 43..70 | CDD:341334 | 7/26 (27%) | ||
| TM helix 2 | 77..102 | CDD:341334 | 7/26 (27%) | ||
| Chemokine binding. /evidence=ECO:0000250 | 98..101 | 1/2 (50%) | |||
| TM helix 3 | 113..143 | CDD:341334 | 11/32 (34%) | ||
| Chemokine binding. /evidence=ECO:0000250 | 117..121 | 1/3 (33%) | |||
| Involved in dimerization, when bound to chemokine. /evidence=ECO:0000250 | 139..151 | 4/11 (36%) | |||
| TM helix 4 | 155..177 | CDD:341334 | 6/22 (27%) | ||
| Chemokine binding, important for signaling. /evidence=ECO:0000250 | 190..194 | 0/3 (0%) | |||
| TM helix 5 | 203..232 | CDD:341334 | 4/28 (14%) | ||
| TM helix 6 | 239..269 | CDD:341334 | 10/29 (34%) | ||
| TM helix 7 | 288..313 | CDD:341334 | 8/24 (33%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 338..358 | 7/17 (41%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| 1 | 0.910 | |||||