DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Octbeta2R and adrb2b

DIOPT Version :9

Sequence 1:	NP_001163596.2	Gene:	Octbeta2R / 41549	FlyBaseID:	FBgn0038063	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_001082940.2	Gene:	adrb2b / 100037315	ZFINID:	ZDB-GENE-070410-32	Length:	409	Species:	Danio rerio

Alignment Length:	418	Identity:	138/418 - (33%)
Similarity:	214/418 - (51%)	Gaps:	74/418 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 NALAATGSSSASNSSTGGIALPLGTATPATHELNATQPFGGSGLNFNESGAGLSDHHHHQQHNPD 144
            |.|....:|...|.|.|               |||:.|...|...::::..
Zfish     5 NTLITENTSLYMNISAG---------------LNASSPVSLSVSEYSDAEV-------------- 40

  Fly   145 EDWLDNIVWVFKAFVMLLIIIAAICGNLLVIISVMRVRKLRVITNYFVVSLAMADIMVAIMAMTF 209
                     |..:.::.::::..:.||.|||.:::|.::|:.:||||:.|||.||:::.:|.:.|
Zfish    41 ---------VLISILIGILVLVIVFGNALVISAIVRFQRLQTVTNYFISSLACADLVMGLMVVPF 96

  Fly   210 NFSVQVTGRWNFSPFLCDLWNSLDVYFSTASILHLCCISVDRYYAIVKPLKYPISMTKRVVGIML 274
            .....:...|:|..|.|:.|.:.||...||||..||.|::|||.||:.||:|...:|||....|:
Zfish    97 GACYILLNTWHFGNFFCEFWTATDVLCVTASIETLCVIALDRYIAIMWPLRYQSMLTKRKACGMV 161

  Fly   275 LNTWISPALLSFLPIFIGWYTTPQHQQF-VIQNPTQCSFVVNKYYAVISSSISFWIPCTIMIFTY 338
            :..|...||:|||||.:.|:.:.:.:.. .::.||.|.|..|..|||.||.|||:||..||.|.|
Zfish   162 IGVWAVAALISFLPIHMEWWVSDEPEALSCLEEPTCCDFNTNAAYAVTSSIISFYIPLVIMAFVY 226

  Fly   339 LAIFREANRQEKQLMMRHGNAMLMHRPSMQPSGEALSGSGSSKTLTLHEVEQEHTPTKDKHLIKM 403
            ..:|:||.||.:::                   :.:.|...:::|:    .||....|::.....
Zfish   227 SRVFQEARRQLQKI-------------------DRIEGRIRTQSLS----TQEGNEIKNRRTKFC 268

  Fly   404 KREHKAARTLGIIMGTFILCWLPFFLWYTLSMTCEECQVPDIVV--SILFWIGYFNSTLNPLIYA 466
            .::|||.:|||||||||.|||||||:   |::.....::.:|::  .||.||||.||..|||||.
Zfish   269 MKDHKALKTLGIIMGTFTLCWLPFFV---LNVVAAIWKMDNIMLPFRILNWIGYANSAFNPLIYC 330

  Fly   467 YFNRDFREAFRNTLLCLFCNWWKDRHLP 494
            . :.:||.||:. :||     |:..|||
Zfish   331 R-SPEFRCAFQE-ILC-----WRPSHLP 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta2R	NP_001163596.2	7tm_4	164..>342	CDD:304433	72/178 (40%)
Octbeta2R	NP_001163596.2	7tm_1	170..465	CDD:278431	114/297 (38%)
adrb2b	NP_001082940.2	7tm_GPCRs	41..339	CDD:333717	119/324 (37%)
		TM helix 1	43..67	CDD:320095	5/23 (22%)
		TM helix 2	76..98	CDD:320095	10/21 (48%)
		TM helix 3	114..136	CDD:320095	10/21 (48%)
		TM helix 4	159..175	CDD:320095	6/15 (40%)
		TM helix 5	204..227	CDD:320095	13/22 (59%)
		TM helix 6	272..297	CDD:320095	20/27 (74%)
		TM helix 7	308..333	CDD:320095	13/25 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H30948
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24248
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X822
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.010