DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Octbeta2R and npy2r

DIOPT Version :9

Sequence 1:	NP_001163596.2	Gene:	Octbeta2R / 41549	FlyBaseID:	FBgn0038063	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	XP_001343301.3	Gene:	npy2r / 100003852	ZFINID:	ZDB-GENE-040924-8	Length:	379	Species:	Danio rerio

Alignment Length:	342	Identity:	90/342 - (26%)
Similarity:	145/342 - (42%)	Gaps:	83/342 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 IIIAAICGNLLVIISVMRVRKLRVITNYFVVSLAMADIMVAIMAMTFNFSVQVTGRWNFSPFLCD 227
            ||...:.||.|||..|.:.|.|..:||||:|:||:||::|..:.:.|.....:.|.|.|...:|.
Zfish    60 IIFFGMTGNSLVIYVVYKFRNLHTVTNYFIVNLAVADLLVNTLCLPFTLMYTLYGEWKFGQVMCY 124

  Fly   228 LW---NSLDVYFSTASILHLCCISVDRYYAIVKPLKYPISMTKRVVGIMLLNTWISPALL-SFLP 288
            |.   ..|.|:.||   :.|..|::|||.:||..::  ..|:|.:..:::..||::.|:| |.|.
Zfish   125 LLPYAQGLAVHVST---ITLNVIALDRYRSIVYHME--TKMSKDMCVVVIAITWVASAILASPLA 184

  Fly   289 IFIGWYTTPQHQQFVIQNPTQC------SFVVNKYYAVISSSISFWIPCTIMIFTYLAIFREANR 347
            ||..:.|.....:..||.   |      |......|::....:.:.:|.:|:.|.|..|:.:.
Zfish   185 IFREYVTFDLSPEQTIQG---CAEKWPGSSTDGTIYSIAMFFLQYGLPLSIISFAYTRIWNKL-- 244

  Fly   348 QEKQLMMRHGNAMLMHRPSMQPSGEALSGSGSSKTLTLHEVEQEHTPTKDKHLIKMKREHKAART 412
                            |..:.|      |.|.|                |:|    :|..|..:.
Zfish   245 ----------------RNHVSP------GGGRS----------------DRH----QRRQKTTKM 267

  Fly   413 LGIIMGTFILCWLPFFLWYTLSMTCEECQVPDIVVSIL-----------FWIGYFNSTL-NPLIY 465
            |..::..|.:.||||.. :.|::        ||..|:|           |.|....||. ||::|
Zfish   268 LVAVVVVFTVSWLPFHA-FQLAV--------DIDSSVLEMKDFKLLYTAFHIVAMCSTFANPILY 323

  Fly   466 AYFNRDFREAFRNTLLC 482
            .:.||::|.:|.....|
Zfish   324 GWMNRNYRGSFVAVFKC 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta2R	NP_001163596.2	7tm_4	164..>342	CDD:304433	56/187 (30%)
Octbeta2R	NP_001163596.2	7tm_1	170..465	CDD:278431	82/316 (26%)
npy2r	XP_001343301.3	7tm_GPCRs	51..334	CDD:333717	88/334 (26%)
		TM helix 1	53..77	CDD:320095	8/16 (50%)
		TM helix 2	86..108	CDD:320095	10/21 (48%)
		TM helix 3	124..146	CDD:320095	7/24 (29%)
		TM helix 4	167..183	CDD:320095	5/15 (33%)
		TM helix 5	215..238	CDD:320095	4/22 (18%)
		TM helix 6	262..287	CDD:320095	7/25 (28%)
		TM helix 7	302..327	CDD:320095	7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910