DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG5608 and VAC14

DIOPT Version :9

Sequence 1:NP_650208.1 Gene:CG5608 / 41543 FlyBaseID:FBgn0038058 Length:687 Species:Drosophila melanogaster
Sequence 2:XP_005256095.1 Gene:VAC14 / 55697 HGNCID:25507 Length:790 Species:Homo sapiens


Alignment Length:726 Identity:330/726 - (45%)
Similarity:456/726 - (62%) Gaps:100/726 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 EPPYAPLSESCAKALGDKVYEKRKLASQEIEKMVTEFNNKNNSAQIRKLIEVLATDYATSRDANR 66
            |..:|||:.:..:||.||:|||||:|:.||||:|.||..:||:.||:.:|:.|:.::|.|:..:.
Human     4 EKDFAPLTPNIVRALNDKLYEKRKVAALEIEKLVREFVAQNNTVQIKHVIQTLSQEFALSQHPHS 68

  Fly    67 RKGALIGLAAMGLGLGKDSGKYVQGMVTPIMTCLSDPDIRVRYFACESLYNVVKVARSAIIPFFP 131
            |||.||||||..:.||||||.|::.::.|::||.:|.|.|:||:|||:|||:|||||.|::|.|.
Human    69 RKGGLIGLAACSIALGKDSGLYLKELIEPVLTCFNDADSRLRYYACEALYNIVKVARGAVLPHFN 133

  Fly   132 ELFAALSRLVTDSDQMVKDGSELLDRLLKDIVTESSQTFNLQAFIPLLREHIYVKDAFARQYVIS 196
            .||..||:|..|.|..||.||||||||||||||||:: |:|.:|||||||.||..:.:|||::||
Human   134 VLFDGLSKLAADPDPNVKSGSELLDRLLKDIVTESNK-FDLVSFIPLLRERIYSNNQYARQFIIS 197

  Fly   197 WISILNAVPDINMVNYLTEILDGLFVMLEDNTLEIQRMCETTISQFLKSIRNDSSSVRMEDTINT 261
            ||.:|.:|||||:::||.|||||||.:|.||..||::|||..:.:|||.|:.:.|||:..:..|.
Human   198 WILVLESVPDINLLDYLPEILDGLFQILGDNGKEIRKMCEVVLGEFLKEIKKNPSSVKFAEMANI 262

  Fly   262 LITHAQSPNELIKSIAITWIREFVQIFGPNVLPYASGIFTAILPCLEYNVESKRSIKECAVSVNN 326
            |:.|.|:.::||:..|:.|:|||:|:.|..:|||:|||.||:||||.|: :.|:||||.|...|.
Human   263 LVIHCQTTDDLIQLTAMCWMREFIQLAGRVMLPYSSGILTAVLPCLAYD-DRKKSIKEVANVCNQ 326

  Fly   327 SMMLLVSTK-----EL----------------KTETVAK-------------------------- 344
            |:|.||:.:     ||                |.|..|.                          
Human   327 SLMKLVTPEDDELDELRPGQRQAEPTPDDALPKQEGTASGGPDGSCDSSFSSGISVFTAASTERA 391

  Fly   345 ---IDLRSIMDVLSQYLTHNS--MHTKIAVLKWIHHLFTNFPNEMSVHASNLNTNLLSTLADNSD 404
               :.|..|:.||:.:|:..:  |.|:||||||::||:...|.:|..|..:|...||.||:|.||
Human   392 PVTLHLDGIVQVLNCHLSDTAIGMMTRIAVLKWLYHLYIKTPRKMFRHTDSLFPILLQTLSDESD 456

  Fly   405 EVVLQSLSVLAEIVNSQESR-------ELNDFNKSH----------------------------- 433
            ||:|:.|.|||||.:|...:       :..|...||                             
Human   457 EVILKDLEVLAEIASSPAGQTDDPGPLDGPDLQASHSELQVPTPGRAGLLNTSGTKGLECSPSTP 521

  Fly   434 -----YRKFLLSLLNLFSEEKLILENRASLIIRKLCVLLNAEYIYRTFAEIIAEGVPNLKFASTV 493
                 :.||:::||..||.|:.:||.|...|||:||:|||||.|:.:.|:|:.. ..:||||||:
Human   522 TMNSYFYKFMINLLKRFSSERKLLEVRGPFIIRQLCLLLNAENIFHSMADILLR-EEDLKFASTM 585

  Fly   494 VRLLNMILLTSTELFELRTSLRNISNEKSADLFQCLYKSWAHCPVSTLSLCLLTQSYQHVSRLVT 558
            |..||.|||||||||:||..|:::...:|.:||.|||:||.|.||:|:|||.|||:|:|...|:.
Human   586 VHALNTILLTSTELFQLRNQLKDLKTLESQNLFCCLYRSWCHNPVTTVSLCFLTQNYRHAYDLIQ 650

  Fly   559 LFADVEITLELLTEFDKLVQLIESPIFAPLRLTLVSKANNCADAQYLAHALFGILMLLPQTEAFD 623
            .|.|:|:|::.|.|.||||||||.|||..|||.|:...||    .||..||:|:||||||:.||.
Human   651 KFGDLEVTVDFLAEVDKLVQLIECPIFTYLRLQLLDVKNN----PYLIKALYGLLMLLPQSSAFQ 711

  Fly   624 TLRNRLQCVPN 634
            .|.:|||||||
Human   712 LLSHRLQCVPN 722

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5608NP_650208.1 HEAT repeat 45..79 CDD:293787 15/33 (45%)
Vac14_Fab1_bd 65..161 CDD:289521 56/95 (59%)
HEAT repeat 91..121 CDD:293787 15/29 (52%)
HEAT repeat 132..161 CDD:293787 18/28 (64%)
HEAT repeat 172..201 CDD:293787 17/28 (61%)
Vac14_Fig4_bd 452..629 CDD:288745 95/176 (54%)
VAC14XP_005256095.1 HEAT repeat 12..36 CDD:293787 13/23 (57%)
Vac14_Fab1_bd 67..163 CDD:289521 56/95 (59%)
HEAT repeat 94..122 CDD:293787 14/27 (52%)
HEAT repeat 134..163 CDD:293787 18/28 (64%)
HEAT repeat 175..204 CDD:293787 17/28 (61%)
HEAT repeat 214..243 CDD:293787 16/28 (57%)
Vac14_Fig4_bd 543..717 CDD:288745 95/178 (53%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165140988
Domainoid 1 1.000 219 1.000 Domainoid score I2652
eggNOG 1 0.900 - - E1_KOG0212
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H6528
Inparanoid 1 1.050 591 1.000 Inparanoid score I990
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG54109
OrthoDB 1 1.010 - - D227979at33208
OrthoFinder 1 1.000 - - FOG0004012
OrthoInspector 1 1.000 - - oto89073
orthoMCL 1 0.900 - - OOG6_102134
Panther 1 1.100 - - LDO PTHR16023
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1626
SonicParanoid 1 1.000 - - X3296
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.800

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