Protein Alignment CG5608 and vac14

DIOPT Version :10

• Sequence 1: NP_650208.1
• Gene: CG5608 / 41543
• FlyBaseID: FBgn0038058
• Length: 687
• Species: Drosophila melanogaster
• Sequence 2: XP_009296175.2
• Gene: vac14 / 447912
• ZFINID: ZDB-GENE-040912-82
• Length: 782
• Species: Danio rerio
• Alignment Length: 784
• Identity: 347/784 - (44%)
• Similarity: 492/784 - (62%)
• Gaps: 118/784 - (15%)

  Fly     2 EPPYAPLSESCAKALGDKVYEKRKLASQEIEKMVTEFNNKNNSAQIRKLIEVLATDYATSRDANR 66
            |..::||:.:..:||.||:|||||:|:.||||:|.||..:|||||||.:|::|||::|.|:..:.
Zfish     4 EKDFSPLTPNIVRALNDKLYEKRKVAALEIEKLVREFVAQNNSAQIRHVIQILATEFALSQHPHS 68

  Fly    67 RKGALIGLAAMGLGLGKDSGKYVQGMVTPIMTCLSDPDIRVRYFACESLYNVVKVARSAIIPFFP 131
            |||.||||||..:.||||||.|::.::.|::||.:|.|.|:||:|||:|||:|||||.|::|.|.
Zfish    69 RKGGLIGLAACSIALGKDSGLYLKELIDPVLTCFNDSDSRLRYYACEALYNIVKVARGAVLPHFN 133

  Fly   132 ELFAALSRLVTDSDQMVKDGSELLDRLLKDIVTESSQTFNLQAFIPLLREHIYVKDAFARQYVIS 196
            .||..||:|..|.|..||.||||||||||||||||:: |:|.||:|||||.||..:.:|||::||
Zfish   134 VLFDGLSKLAADPDPNVKSGSELLDRLLKDIVTESNK-FDLVAFVPLLRERIYSNNQYARQFIIS 197

  Fly   197 WISILNAVPDINMVNYLTEILDGLFVMLEDNTLEIQRMCETTISQFLKSIRNDSSSVRMEDTINT 261
            ||.:|.:|||||:::||.|||||||.:|.|::.||:||||..:.:|||.|:.:.|||:..:..|.
Zfish   198 WIHVLESVPDINLLDYLPEILDGLFQILGDSSKEIRRMCELVLGEFLKEIKKNPSSVKFAEMANI 262

  Fly   262 LITHAQ------SPNELIKSIAITWIREFVQIFGPNVLPYASGIFTAILPCLEYNVESKRSIKEC 320
            |:.|.|      |.|:||:..::||:|||:|:.|..||||:|||.||:||||.|: :.|:|.||.
Zfish   263 LVIHCQVSDESKSTNDLIQLTSMTWMREFIQLAGRVVLPYSSGILTAVLPCLSYD-DRKKSTKEA 326

  Fly   321 AVSVNNSMMLLVS------TKELKTE--------------------------------------- 340
            |.:.|:|:|.||:      .:|.:|:
Zfish   327 ASACNHSLMKLVTPEDDEDDEESQTKSSPPSDEAPSKKEGDLNDSLNESQESVGFSNISFFTPAS 391

  Fly   341 ---TVAKIDLRSIMDVLSQYLTHNS---MHTKIAVLKWIHHLFTNFPNEMSVHASNLNTNLLSTL 399
               :...:||..|:.||.::| |:|   |.|:||||||::||:...|.:|..|..:|...||.||
Zfish   392 SDRSAVTLDLDGIVQVLDRHL-HDSSTGMMTRIAVLKWLYHLYIKTPRKMFKHTDSLFPMLLKTL 455

  Fly   400 ADNSDEVVLQSLSVLAEIVNSQESR--------------------------------ELNDFN-- 430
            :|.||||:|:.|.|||||.:|...:                                ::.|.:
Zfish   456 SDESDEVILKDLEVLAEIASSPAGQTDTSGSCDISDSKTKLHIPGGVRDGQPVVVGSKMTDLSPS 520

  Fly   431 ----KSHYRKFLLSLLNLFSEEKLILENRASLIIRKLCVLLNAEYIYRTFAEIIAEGVPNLKFAS 491
                .|::.||:::||..||.|:.:||.|.:.|||:||:||:||.|:.:.|:|:.: ..:|||||
Zfish   521 TPSMNSYFYKFMINLLKRFSLERKLLEMRGAFIIRQLCLLLHAENIFHSMADILLK-EEDLKFAS 584

  Fly   492 TVVRLLNMILLTSTELFELRTSLRNISNEKSADLFQCLYKSWAHCPVSTLSLCLLTQSYQHVSRL 556
            |:|:.||.|||||.|||:||..|:::..::|..||.|||:||.|.||:|:|||.|||:|:|...|
Zfish   585 TMVQTLNTILLTSAELFQLRNQLKDLRTQESCALFCCLYRSWCHNPVATVSLCFLTQNYRHAYDL 649

  Fly   557 VTLFADVEITLELLTEFDKLVQLIESPIFAPLRLTLVSKANNCADAQYLAHALFGILMLLPQTEA 621
            :..|.|:|:|::.|.|.||||||||||||..|||.|:...:|    .||..||:|:||||||::|
Zfish   650 IQKFGDLEVTVDFLMEVDKLVQLIESPIFTYLRLQLLDVEHN----PYLIKALYGLLMLLPQSQA 710

  Fly   622 FDTLRNRLQCVPNYWGHEP------VDERNSLEYK----SGIDFDALEQHFIKLQKAHREQRIVH 676
            |..|.:||.||||     |      .|::.:::.|    ..||:..|.|||.::|..|.|.|...
Zfish   711 FQLLSHRLSCVPN-----PELMRTLEDQKVAVKDKHLAQPHIDYSELLQHFDRVQSKHLEVRHQR 770

  Fly   677 RKRS 680
            ..||
Zfish   771 TGRS 774

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5608	NP_650208.1	HEAT repeat	45..79	CDD:293787	19/33 (58%)
		Vac14_Fab1_bd	65..161	CDD:403838	56/95 (59%)
		HEAT repeat	91..121	CDD:293787	15/29 (52%)
		Adaptin_N	<92..>427	CDD:396262	175/423 (41%)
		HEAT repeat	132..161	CDD:293787	18/28 (64%)
		HEAT repeat	172..201	CDD:293787	17/28 (61%)
		Vac14_Fig4_bd	452..632	CDD:463395	95/179 (53%)
vac14	XP_009296175.2	None