DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG5608 and Vac14

DIOPT Version :9

Sequence 1:NP_650208.1 Gene:CG5608 / 41543 FlyBaseID:FBgn0038058 Length:687 Species:Drosophila melanogaster
Sequence 2:NP_666328.2 Gene:Vac14 / 234729 MGIID:2157980 Length:782 Species:Mus musculus


Alignment Length:778 Identity:353/778 - (45%)
Similarity:482/778 - (61%) Gaps:113/778 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 EPPYAPLSESCAKALGDKVYEKRKLASQEIEKMVTEFNNKNNSAQIRKLIEVLATDYATSRDANR 66
            |..:|||:.:..:||.||:|||||:|:.||||:|.:|..:||:.||:.:|:.|:.::|.|:..:.
Mouse     4 EKDFAPLTPNIVRALNDKLYEKRKVAALEIEKLVRDFVAQNNTMQIKHVIQTLSQEFALSQHPHS 68

  Fly    67 RKGALIGLAAMGLGLGKDSGKYVQGMVTPIMTCLSDPDIRVRYFACESLYNVVKVARSAIIPFFP 131
            |||.||||||..:.||||||.|::.::.|::||.:|.|.|:||:|||:|||:|||||.|::|.|.
Mouse    69 RKGGLIGLAACSIALGKDSGLYLKELIEPVLTCFNDADSRLRYYACEALYNIVKVARGAVLPHFN 133

  Fly   132 ELFAALSRLVTDSDQMVKDGSELLDRLLKDIVTESSQTFNLQAFIPLLREHIYVKDAFARQYVIS 196
            .||..||:|..|.|..||.|||||||||||||||||: |:|.:|||||||.||..:.:|||::||
Mouse   134 VLFDGLSKLAADPDPNVKSGSELLDRLLKDIVTESSK-FDLVSFIPLLRERIYSNNQYARQFIIS 197

  Fly   197 WISILNAVPDINMVNYLTEILDGLFVMLEDNTLEIQRMCETTISQFLKSIRNDSSSVRMEDTINT 261
            ||.:|.:|||||:::||.|||||||.:|.||..||::|||..:.:|||.|:.:.|||:..:..|.
Mouse   198 WILVLVSVPDINLLDYLPEILDGLFQILGDNGKEIRKMCEVVLGEFLKEIKKNPSSVKFAEMANI 262

  Fly   262 LITHAQSPNELIKSIAITWIREFVQIFGPNVLPYASGIFTAILPCLEYNVESKRSIKECAVSVNN 326
            |:.|.|:.::||:..|:.|:|||:|:.|..:|||:|||.||:||||.|: :.|:||||.|...|.
Mouse   263 LVIHCQTTDDLIQLTAMCWMREFIQLAGRVMLPYSSGILTAVLPCLAYD-DRKKSIKEVANVCNQ 326

  Fly   327 SMMLLV-----------STKELKTE--------------------------------TVAKID-- 346
            |:|.||           |..:.:||                                |.|..|  
Mouse   327 SLMKLVTPEDDEPDEPKSVAQKQTEPNPEDSLPKQEGTASGGPGSCDSSFGSGINVFTSANTDRA 391

  Fly   347 -----LRSIMDVLSQYLTHNS--MHTKIAVLKWIHHLFTNFPNEMSVHASNLNTNLLSTLADNSD 404
                 |..|:.||:.:|:..:  |.|:||||||::||:...|.:|..|..:|...||.||:|.||
Mouse   392 PVTLHLDGIVQVLNCHLSDTTIGMMTRIAVLKWLYHLYIKTPRKMFRHTDSLFPILLQTLSDESD 456

  Fly   405 EVVLQSLSVLAEI--------------------VNSQE-----SRELNDFN-------------- 430
            ||||:.|.|||||                    ||..|     |...|..|              
Mouse   457 EVVLKDLEVLAEIASSPAGQTDDPGAPDGPDLRVNHSELQVPTSGRANLLNPPSTKGLEGSPSTP 521

  Fly   431 --KSHYRKFLLSLLNLFSEEKLILENRASLIIRKLCVLLNAEYIYRTFAEIIAEGVPNLKFASTV 493
              .|::.||:::||..||.|:.:||.|...|||:||:|||||.|:.:.|:|:.. ..:||||||:
Mouse   522 TMNSYFYKFMINLLQTFSSERKLLEARGPFIIRQLCLLLNAENIFHSMADILLR-EEDLKFASTM 585

  Fly   494 VRLLNMILLTSTELFELRTSLRNISNEKSADLFQCLYKSWAHCPVSTLSLCLLTQSYQHVSRLVT 558
            |..||.|||||||||:||..|:::...:|.:||.|||:||.|.||:|:|||.|||:|:|...|:.
Mouse   586 VHTLNTILLTSTELFQLRNQLKDLQTPESQNLFCCLYRSWCHNPVTTVSLCFLTQNYRHAYDLIQ 650

  Fly   559 LFADVEITLELLTEFDKLVQLIESPIFAPLRLTLVSKANNCADAQYLAHALFGILMLLPQTEAFD 623
            .|.|:|:|::.|||.||||||||.|||..|||.|:...||    .||..||:|:||||||:.||.
Mouse   651 KFGDLEVTVDFLTEVDKLVQLIECPIFTYLRLQLLDVKNN----PYLIKALYGLLMLLPQSSAFQ 711

  Fly   624 TLRNRLQCVPNYWGHEPVDERNSLEY--KS------GIDFDALEQHFIKLQKAHREQRIVHRK 678
            .|.:|||||||   .|.:...:.|:.  ||      .||:..|.|||.|:||.|.|.|  |::
Mouse   712 LLSHRLQCVPN---PELLQTEDCLKAAPKSQKGDSPSIDYTELLQHFEKVQKQHLEVR--HQR 769

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5608NP_650208.1 HEAT repeat 45..79 CDD:293787 15/33 (45%)
Vac14_Fab1_bd 65..161 CDD:289521 56/95 (59%)
HEAT repeat 91..121 CDD:293787 15/29 (52%)
HEAT repeat 132..161 CDD:293787 18/28 (64%)
HEAT repeat 172..201 CDD:293787 17/28 (61%)
Vac14_Fig4_bd 452..629 CDD:288745 96/176 (55%)
Vac14NP_666328.2 HEAT 1 5..42 19/36 (53%)
HEAT repeat 12..35 CDD:293787 12/22 (55%)
Vac14_Fab1_bd 67..163 CDD:289521 56/95 (59%)
HEAT 2 89..126 19/36 (53%)
HEAT repeat 94..122 CDD:293787 14/27 (52%)
HEAT repeat 134..163 CDD:293787 18/28 (64%)
HEAT 3 171..208 21/36 (58%)
HEAT repeat 175..204 CDD:293787 17/28 (61%)
HEAT 4 212..249 21/36 (58%)
HEAT repeat 214..243 CDD:293787 16/28 (57%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 331..371 5/39 (13%)
HEAT 5 438..475 19/36 (53%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 471..519 6/47 (13%)
Vac14_Fig4_bd 543..717 CDD:288745 96/178 (54%)
HEAT 6 560..598 21/38 (55%)
Mediates interaction with the PDZ domain of NOS1. /evidence=ECO:0000250 773..777
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167830943
Domainoid 1 1.000 221 1.000 Domainoid score I2596
eggNOG 1 0.900 - - E1_KOG0212
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H6528
Inparanoid 1 1.050 596 1.000 Inparanoid score I959
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG54109
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0004012
OrthoInspector 1 1.000 - - oto92641
orthoMCL 1 0.900 - - OOG6_102134
Panther 1 1.100 - - LDO PTHR16023
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1626
SonicParanoid 1 1.000 - - X3296
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1615.790

Return to query results.
Submit another query.