Protein Alignment Polr3C and POLR3C

DIOPT Version :10

• Sequence 1: NP_650207.1
• Gene: Polr3C / 41542
• FlyBaseID: FBgn0038057
• Length: 522
• Species: Drosophila melanogaster
• Sequence 2: NP_001290385.1
• Gene: POLR3C / 10623
• HGNCID: 30076
• Length: 547
• Species: Homo sapiens
• Alignment Length: 539
• Identity: 181/539 - (33%)
• Similarity: 281/539 - (52%)
• Gaps: 50/539 - (9%)

  Fly     8 LSSAILEQCFGKVVQAVADCLFSATTRTLGQITSATKLSRKEVAFALAVLVKFRLVDFAASKANP 72
            |.|.:|::.||::|:.:...|....::.|..|...|..|..:|..||.|||:..||.:...|..
Human    21 LCSLLLQEHFGEIVEKIGVHLIRTGSQPLRVIAHDTGTSLDQVKKALCVLVQHNLVSYQVHKRG- 84

  Fly    73 FLAEYALRREDVLCLLRYPRYVHLVQTKYGNVGASISEELINSGSDTATGILLKC---LAE--NE 132
             :.||..:...||.:||||||::..:|.|.:.|..|.|||:.:|..|.:.::.|.   |.|  .:
Human    85 -VVEYEAQCSRVLRMLRYPRYIYTTKTLYSDTGELIVEELLLNGKLTMSAVVKKVADRLTETMED 148

  Fly   133 NKAESPESYRNTFLEMITDHYIIKRPELLVGDDQDEN----VPKFETNECDFFRHPNIDLQLLAK 193
            .|........|||:.:...|::.:.|.:...::.|..    .|....||.|.:..|.:.|
Human   149 GKTMDYAEVSNTFVRLADTHFVQRCPSVPTTENSDPGPPPPAPTLVINEKDMYLVPKLSL----- 208

  Fly   194 IQKG-------EATLAEAR---------------DSHMVWHLNHDRFHQDFRDTIMVDAIERKLG 236
            |.||       |....|.:               |..:.|..|.|||||.|||..:|.|:..::.
Human   209 IGKGKRRRSSDEDAAGEPKAKRPKYTTDNKEPIPDDGIYWQANLDRFHQHFRDQAIVSAVANRMD 273

  Fly   237 ENAAECFKFILKIMYNTTD---PWERKLSNQITFVEIKQAIERKSNNLDLMKYLDQYISLLTEDS 298
            :.::|..:.:|::...||.   |:.:.||:...|..:....     |:. .:.||||::||.:|.
Human   274 QTSSEIVRTMLRMSEITTSSSAPFTQPLSSNEIFRSLPVGY-----NIS-KQVLDQYLTLLADDP 332

  Fly   299 LGFFRRVGDMGGGVYVVDMEHAFESLAFACVECVITERFGSKAARIFRVIRCKKYIEQEDLQKEA 363
            |.|..:.||.|||:||:::..|..|||.|.:|.|:.|||||:.|||||::..||:|||:.::..|
Human   333 LEFVGKSGDSGGGMYVINLHKALASLATATLESVVQERFGSRCARIFRLVLQKKHIEQKQVEDFA 397

  Fly   364 MIPSKEAKSLAYNLFQEQFIHVKIIKKPGGGSNGPAKAFYLFQVKEKDTVRMLLDASYKSLYNTI 428
            |||:||||.:.|.:..|.|:.::.|  |....:.|::.|||:.|......||||...|||:.|.|
Human   398 MIPAKEAKDMLYKMLSENFMSLQEI--PKTPDHAPSRTFYLYTVNILSAARMLLHRCYKSIANLI 460

  Fly   429 ERSNFEKNEHKGLIEKSQRLDSIVEAMKERGETDEYIAEIVETFTPPECEILNKVKNRIKTLSKA 493
            ||..||..|:|.|:|||||:::|:.:|:..|..:..:.||.|..|.||.:.|..:|..:..|..:
Human   461 ERRQFETKENKRLLEKSQRVEAIIASMQATGAEEAQLQEIEEMITAPERQQLETLKRNVNKLDAS 525

  Fly   494 ELTLDDTIFLLQMYQHHCT 512
            |:.:|:|||||:.| ..||
Human   526 EIQVDETIFLLESY-IECT 543

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Polr3C	NP_650207.1	HTH_9	7..67	CDD:400500	19/58 (33%)
		RNA_pol_Rpc82	143..324	CDD:398977	56/209 (27%)
POLR3C	NP_001290385.1	HTH_9	20..78	CDD:400500	19/56 (34%)
		RNA_pol_Rpc82	159..358	CDD:398977	56/209 (27%)