DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5961 and Fbxo9

DIOPT Version :9

Sequence 1:	NP_001189211.1	Gene:	CG5961 / 41541	FlyBaseID:	FBgn0038056	Length:	442	Species:	Drosophila melanogaster
Sequence 2:	NP_001074959.1	Gene:	Fbxo9 / 71538	MGIID:	1918788	Length:	437	Species:	Mus musculus

Alignment Length:	460	Identity:	168/460 - (36%)
Similarity:	236/460 - (51%)	Gaps:	53/460 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SDVDSDGEE----PTRKTGTNALDEFRENWQRELQEHTTNTGSRSHSE-----AG--DRLTAANS 55
            ||.|..|:|    |..:.....|..||..|..||   |...|| ||.|     ||  ..|.||..
Mouse    11 SDADRVGDEGNESPAERDLQAQLQMFRAQWMFEL---TPGVGS-SHGETRPCRAGRSSMLKAAAD 71

  Fly    56 NLSEADLL-QAKAESLYRTAVQLEQRGKVYDALPFYRKATQIVPDIEFRF-YEQQKQKLSNDVSK 118
            .....:|. :.||..|:..||:.||.|.:|:|:.|||:|.|:||||||:. |.:...  .:.|..
Mouse    72 TKGRQELAKEEKARELFLQAVEEEQNGALYEAIKFYRRAMQLVPDIEFKITYTRSPD--GDGVGS 134

  Fly   119 KYLNLANDLAKQLDLGQSDGEEVVDNLYEKFQHDLRQKNIYNGKMIASSRDANVLTTGLHFADLP 183
            .|:....|.:|..|            |...||..|..:     :.:.......:.|:..|.:.||
Mouse   135 GYIEENEDASKMAD------------LLSYFQQQLTLQ-----ESVLKLCQPELETSQTHISVLP 182

  Fly   184 PEIVMRILRWVVSAQLDMRSLEQCAAVCKGFYVYARDEELWRLACVKVWGHNVGTLEAQDSDVSN 248
            .|::|.|.|||||:.||:|||||.:.||:|||:.|||.|:|||||:||||.:...|..
Mouse   183 MEVLMYIFRWVVSSDLDLRSLEQLSLVCRGFYICARDPEIWRLACLKVWGRSCMKLVP------- 240

  Fly   249 VFHSWRDMFIRRDRVLFNGCYISKTTYLRMGENSFQDQFYRPVQLVEYYRYIRFLPDGKVLMMTT 313
             :.|||:||:.|.||.|:|.|||||||:|.||.|. |.|||....||||||:||.|||.|:|:||
Mouse   241 -YASWREMFLERPRVRFDGVYISKTTYIRQGEQSL-DGFYRAWHQVEYYRYMRFFPDGHVMMLTT 303

  Fly   314 ADEPAQGVSKLKHVNNVRAEMLRGRYRLF-----GSTVTLVLQKSQQRGPANVRQRRGSIMPVDE 373
            .:||...|.:|:..|.....:|.|.|||.     .:.|..|:.|.::..|.:.:.|....:||.|
Mouse   304 PEEPPSIVPRLRTRNTRTDAILLGHYRLSQDADNQTKVFAVITKKKEEKPLDHKYRYFRRVPVQE 368

  Fly   374 DSSQFLIELRIAGTTKRRCAQLVWSHYT--LVQKRNKVDISSEFDLTEAKYPALRFSTVKSYHLD 436
            ....|.:.|::..:..:|..:|:|.|::  :..|.......|.|:: :..|..|.|:.|:||...
Mouse   369 ADHSFHVGLQLCSSGHQRFNKLIWIHHSCHITYKATGETAVSAFEI-DKMYTPLLFARVRSYTAF 432

  Fly   437 ADAPL 441
            ::.||
Mouse   433 SERPL 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5961	NP_001189211.1	MIT	74..131	CDD:294211	23/57 (40%)
CG5961	NP_001189211.1	F-box-like	179..225	CDD:289689	26/45 (58%)
Fbxo9	NP_001074959.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27		6/15 (40%)
		MIT	82..>113	CDD:294211	14/30 (47%)
		TPR	84..117		16/32 (50%)
		F-box-like	178..229	CDD:289689	31/50 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842768
Domainoid	1	1.000	128	1.000	Domainoid score	I5312
eggNOG	1	0.900	-	-		E1_KOG2997
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8217
Inparanoid	1	1.050	243	1.000	Inparanoid score	I3293
Isobase	1	0.950	-	0	Normalized mean entropy	S4980
OMA	1	1.010	-	-		QHG46930
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005835
OrthoInspector	1	1.000	-	-		oto94517
orthoMCL	1	0.900	-	-		OOG6_104095
Panther	1	1.100	-	-	LDO	PTHR12874
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R949
SonicParanoid	1	1.000	-	-		X4819
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740