DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5961 and fbxo9

DIOPT Version :9

Sequence 1:	NP_001189211.1	Gene:	CG5961 / 41541	FlyBaseID:	FBgn0038056	Length:	442	Species:	Drosophila melanogaster
Sequence 2:	XP_012818287.1	Gene:	fbxo9 / 394601	XenbaseID:	XB-GENE-1002447	Length:	431	Species:	Xenopus tropicalis

Alignment Length:	473	Identity:	166/473 - (35%)
Similarity:	236/473 - (49%)	Gaps:	74/473 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSDVDSD-------GEEPTRKTGTNALDE---FRENWQRE---------LQEHTTNTGSRSH--- 43
            |::.|.|       ..|..|...||..:|   ||..|..|         |:....|..:|..
Frog     1 MAEGDEDSYTDSLMSNENGRPGETNLQEELQMFRARWMSELTPGLSSGGLENRPCNAAARGPVGK 65

  Fly    44 -SEAGDRLTAANSNLSEADLLQAKAESLYRTAVQLEQRGKVYDALPFYRKATQIVPDIEFRFYEQ 107
             ||     |.|...|::    :|||..|:..|.:.||.|.:|:|:.|||:|.|:||||||:.
Frog    66 VSE-----TKAKQELAK----EAKARELFLKAAEEEQNGALYEAIKFYRQAMQLVPDIEFKI--- 118

  Fly   108 QKQKLSND-VSKKYLNLANDLAKQLDLGQSDGEEVVDNLYEKFQHDLRQKNIYNGKMIASSRDAN 171
             ....|.| .:|.:|:.||:.:|..|            |...||   :|......|:.....|
Frog   119 -NYTWSPDGDTKNFLDDANNDSKMAD------------LLSYFQ---QQLTFQQSKLCQPDID-- 165

  Fly   172 VLTTGLHFADLPPEIVMRILRWVVSAQLDMRSLEQCAAVCKGFYVYARDEELWRLACVKVWGHNV 236
              .|..|.:.||.|::|.|.|||||:.||:|:|||.:.||||||:.|||.|:|||||:||||.|.
Frog   166 --VTQTHISVLPMEVLMYIFRWVVSSDLDLRALEQLSLVCKGFYICARDPEIWRLACLKVWGRNC 228

  Fly   237 GTLEAQDSDVSNVFHSWRDMFIRRDRVLFNGCYISKTTYLRMGENSFQDQFYRPVQLVEYYRYIR 301
            ..:..        :.:||.||:.|.||.|:|.|||||||:|.||.|. |.|||....||||||:|
Frog   229 VKIVP--------YTTWRQMFLERPRVRFDGVYISKTTYIRQGEQSL-DGFYRAWHQVEYYRYLR 284

  Fly   302 FLPDGKVLMMTTADEPAQGVSKLKHVNNVRAEMLRGRYRLFGST-----VTLVLQKSQQRGPANV 361
            |.|||.|:|:||.::|...|.:|:..|.....||.|.|||...|     |..|:...::..|::.
Frog   285 FFPDGHVMMLTTPEDPQTIVPRLRTKNARTDAMLLGHYRLSQDTDNQTKVFAVITNKKEEKPSDY 349

  Fly   362 RQRRGSIMP-VDEDSSQFLIELRIAGTTKRRCAQLVWSHYT--LVQKRNKVDISSEFDLTEAKYP 423
            ::.|....| |.|....|.:.|::..:.:.:..:|||.|::  :..|.......:.||: :..|.
Frog   350 QKYRYFRRPQVQETERSFHVGLQLCSSGRHKFNKLVWIHHSCHITYKSTGETAVTAFDI-DKMYT 413

  Fly   424 ALRFSTVKSYHLDADAPL 441
            .:.|..|||:...::.||
Frog   414 PMFFVRVKSFTAVSERPL 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5961	NP_001189211.1	MIT	74..131	CDD:294211	24/57 (42%)
CG5961	NP_001189211.1	F-box-like	179..225	CDD:289689	26/45 (58%)
fbxo9	XP_012818287.1	MIT	80..>110	CDD:381929	13/29 (45%)
fbxo9	XP_012818287.1	F-box-like	171..217	CDD:372399	26/45 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	121	1.000	Domainoid score	I5663
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8217
Inparanoid	1	1.050	229	1.000	Inparanoid score	I3369
OMA	1	1.010	-	-		QHG46930
OrthoDB	1	1.010	-	-		D1407789at2759
OrthoFinder	1	1.000	-	-		FOG0005835
OrthoInspector	1	1.000	-	-		oto104721
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R949
SonicParanoid	1	1.000	-	-		X4819
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.010