DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5961 and fbxo9

DIOPT Version :9

Sequence 1:	NP_001189211.1	Gene:	CG5961 / 41541	FlyBaseID:	FBgn0038056	Length:	442	Species:	Drosophila melanogaster
Sequence 2:	XP_005156544.1	Gene:	fbxo9 / 325469	ZFINID:	ZDB-GENE-030131-4194	Length:	422	Species:	Danio rerio

Alignment Length:	459	Identity:	158/459 - (34%)
Similarity:	235/459 - (51%)	Gaps:	59/459 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SDVDSDG---EEPTRKTGTN----ALDEFRENWQRELQEHTTNTGSRSHSEAGDRLTAANSNL-- 57
            |:.::||   |.....||.:    .|..||..|..|||.          |..|.|..:.|:.|
Zfish     4 SNQNTDGAVEEGEDENTGDSNLQMELSAFRAKWMSELQP----------SSGGQRSFSRNAELRR 58

  Fly    58 SEADLLQAKAESLYRTAVQLEQRGKVYDALPFYRKATQIVPDIEFRF-YEQQKQKLSNDVSKKYL 121
            .:....:.||..|:..||:.||.|.||:|:.:|:.|.|:||||||:. |.:....   :....||
Zfish    59 RQETAKEEKARELFLKAVEEEQNGAVYEAIKYYKSAMQLVPDIEFKINYSRTPDP---ERGGSYL 120

  Fly   122 NLANDLAKQLDLGQSDGEEVVDNLYEKFQHDLRQKNIYNGKMIASSRDANVLTTGLHFADLPPEI 186
            .            .|:....:|:|...|||.|   .:.|..|.....:..  |:.:|.:.||.|:
Zfish   121 E------------SSENNREIDDLLTYFQHQL---TLGNDAMKLCEHETE--TSQVHISALPFEV 168

  Fly   187 VMRILRWVVSAQLDMRSLEQCAAVCKGFYVYARDEELWRLACVKVWGHNVGTLEAQDSDVSNVFH 251
            :|.|.|||||..||:|:|||.:.||:|||:.|||.|:||.||::|||.:...:..        :.
Zfish   169 LMYIFRWVVSCDLDLRALEQLSLVCRGFYICARDPEIWRSACLRVWGRSCTKMLP--------YS 225

  Fly   252 SWRDMFIRRDRVLFNGCYISKTTYLRMGENSFQDQFYRPVQLVEYYRYIRFLPDGKVLMMTTADE 316
            |||:||:.|.||.|:|.|||||:|:|.||.|. |.|||....||||||:||.|||:|:|:||.::
Zfish   226 SWREMFLERPRVRFDGVYISKTSYIRQGEESL-DGFYRAWHQVEYYRYLRFFPDGQVMMLTTPED 289

  Fly   317 PAQGVSKLKHVNNVRAEMLRGRYRLFGST-------VTLVLQKSQQRGPANVRQRRGSIMPVDED 374
            |...|.:|:..|:....::.|.|||...|       |.:..:|.:|:.....|.|.....||.|.
Zfish   290 PLVTVPRLRSKNSRMDSIMFGHYRLSQDTDNQTKVYVVVSKRKEEQKVSEYQRSRFCRRNPVPEA 354

  Fly   375 SSQFLIELRIAGTTKRRCAQLVWSHYT--LVQKRNKVDISSEFDLTEAKYPALRFSTVKSYHLDA 437
            ...|.:.|:::...::|..:|||.|::  :..:.....:.:.||: :..|..|.|:.||||...:
Zfish   355 ERSFHVGLQLSSGGRQRFNKLVWIHHSCHITYRSTGETVVTAFDV-DKMYTPLFFARVKSYTAFS 418

  Fly   438 DAPL 441
            :.||
Zfish   419 ERPL 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5961	NP_001189211.1	MIT	74..131	CDD:294211	20/57 (35%)
CG5961	NP_001189211.1	F-box-like	179..225	CDD:289689	25/45 (56%)
fbxo9	XP_005156544.1	MIT	66..>97	CDD:294211	13/30 (43%)
fbxo9	XP_005156544.1	F-box-like	161..212	CDD:289689	29/50 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170587205
Domainoid	1	1.000	123	1.000	Domainoid score	I5572
eggNOG	1	0.900	-	-		E1_KOG2997
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8217
Inparanoid	1	1.050	235	1.000	Inparanoid score	I3375
OMA	1	1.010	-	-		QHG46930
OrthoDB	1	1.010	-	-		D1407789at2759
OrthoFinder	1	1.000	-	-		FOG0005835
OrthoInspector	1	1.000	-	-		oto40382
orthoMCL	1	0.900	-	-		OOG6_104095
Panther	1	1.100	-	-	LDO	PTHR12874
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R949
SonicParanoid	1	1.000	-	-		X4819
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800