DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5961 and AgaP_AGAP006784

DIOPT Version :9

Sequence 1:	NP_001189211.1	Gene:	CG5961 / 41541	FlyBaseID:	FBgn0038056	Length:	442	Species:	Drosophila melanogaster
Sequence 2:	XP_308962.3	Gene:	AgaP_AGAP006784 / 1270280	VectorBaseID:	AGAP006784	Length:	442	Species:	Anopheles gambiae

Alignment Length:	450	Identity:	188/450 - (41%)
Similarity:	284/450 - (63%)	Gaps:	34/450 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 DSDGEEPTRKTGTNA-------LDEFRENWQRELQEHTTNTGSRSHSEAGDRLTAANSNLSEA-D 61
            |.:....:..:|:.|       ||:|||.||:||::       ..|..:...:..|..|:.:. |
Mosquito    13 DDESSSSSTTSGSEATSPKRSELDDFREQWQKELKK-------EQHVASAATVAPAGGNVGDGKD 70

  Fly    62 LLQAKAESLYRTAVQLEQRGKVYDALPFYRKATQIVPDIEFRFYEQQKQKLSNDVSKKYLNLAND 126
            .::.:|..|::...:||:.|||::|:..||:|||:|||||||.|:::..|.:...::    :...
Mosquito    71 SIEQQARLLFQQGSELERSGKVFEAMRLYRRATQLVPDIEFRVYDKKHAKATTAAAE----VDGL 131

  Fly   127 LAKQLDLGQSDGEEVVD--NLYEKFQHDLRQKNIYNGKMI-ASSRDANVLTTGLHFADLPPEIVM 188
            :.:.|:....:.||.::  :|..:||..:.:    :||:. .:|.|..::.|..||:|||.|:::
Mosquito   132 MERMLEANIDEDEENLEGVDLGLRFQTLMAR----SGKLFERASGDRKLIVTSAHFSDLPMEVIL 192

  Fly   189 RILRWVVSAQLDMRSLEQCAAVCKGFYVYARDEELWRLACVKVWGHNVGTLEAQDSDVSNVFHSW 253
            .|||||||..||::|||:.|:||:|||:.|||.|:||.||:::||.|:|.|:      ...|.||
Mosquito   193 YILRWVVSNDLDLKSLERFASVCRGFYLLARDPEIWRHACMRIWGVNLGVLK------GTPFSSW 251

  Fly   254 RDMFIRRDRVLFNGCYISKTTYLRMGENSFQDQFYRPVQLVEYYRYIRFLPDGKVLMMTTADEPA 318
            |:|:|.|.|:||:|||||:|:|||.||||||||||||:||||||||.||..|||||||||||||.
Mosquito   252 REMYINRPRILFHGCYISRTSYLRSGENSFQDQFYRPIQLVEYYRYFRFFADGKVLMMTTADEPQ 316

  Fly   319 QGVSKLKHVNNVRAEMLRGRYRLFGSTVTLVLQKSQQRGPANVRQRRGSIMPVDEDSSQ--FLIE 381
            |.|.:||.....:.|:|||.|||....|.:|:|:::......:::.......::.:..|  ||:|
Mosquito   317 QCVVRLKQRVPTQNEILRGHYRLHDDIVIVVIQRNRPSAAGQMQRPGRKARDIEPEYGQQTFLME 381

  Fly   382 LRIAGTTKRRCAQLVWSHYTLVQKRNKVDISSEFDLTEAKYPALRFSTVKSYHLDADAPL 441
            |:|..|.||..:||.|..||:||:||..:.:::|:||..|||.|.||.|||||.:::.||
Mosquito   382 LQIVSTGKRPFSQLHWKQYTMVQQRNNQEKTTQFELTTTKYPPLYFSRVKSYHQESEGPL 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5961	NP_001189211.1	MIT	74..131	CDD:294211	20/56 (36%)
CG5961	NP_001189211.1	F-box-like	179..225	CDD:289689	27/45 (60%)
AgaP_AGAP006784	XP_308962.3	F-box-like	183..234	CDD:289689	31/50 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	215	1.000	Domainoid score	I5899
eggNOG	1	0.900	-	-		E1_KOG2997
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8217
Inparanoid	1	1.050	352	1.000	Inparanoid score	I4482
OMA	1	1.010	-	-		QHG46930
OrthoDB	1	1.010	-	-		D1407789at2759
OrthoFinder	1	1.000	-	-		FOG0005835
OrthoInspector	1	1.000	-	-		oto110081
Panther	1	1.100	-	-	LDO	PTHR12874
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4819
TreeFam	1	0.960	-	-
	13	12.940