DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trus and pdcd2l

DIOPT Version :9

Sequence 1:	NP_650205.1	Gene:	trus / 41540	FlyBaseID:	FBgn0038055	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_956517.1	Gene:	pdcd2l / 393192	ZFINID:	ZDB-GENE-040426-967	Length:	357	Species:	Danio rerio

Alignment Length:	484	Identity:	121/484 - (25%)
Similarity:	179/484 - (36%)	Gaps:	156/484 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 TVYLGYEDEEVTAKQEQLLNSCTNKIGGTPD-WPRHEVTIPSCPLCGAVRPLIVQMYAPLDRSQF 70
            ||.:|..|..:..|:.  .:.||||||..|| .|...:..|||.||......:||:|.||..|.:
Zfish     8 TVLIGICDGAIDKKKN--ASYCTNKIGDRPDLLPIITLQYPSCSLCQRGLSHVVQVYCPLAASPY 70

  Fly    71 HRSLYVFGCMNPVCSQNSKSWCCVRTQHLDHQYEVISEHSPK--ATPTKKQNSKKKGKSSGLQAI 133
            ||::.||.|.:|.|...|:||..:|:|.|:...:...:|...  |.||             :...
Zfish    71 HRTINVFACTSPQCYGKSESWIVLRSQCLEDDIKERQDHKTTQCAEPT-------------MSRT 122

  Fly   134 SWCSGADDWGDSSGGATEQAKTISVALDEAMDITADDDQNERNGNVRPNALQYAKSDIQIDEPAK 198
            .||..|||||                :|:.:.|:|                        :::|
Zfish   123 DWCDEADDWG----------------MDDEVAISA------------------------VEKP-- 145

  Fly   199 LEQVKIAADDDDDEDESTSLENELISGFHQMDMISPQNADDDPNANCAAAAAPSLDGAGASAASA 263
            ::.|      .:..|.|:.|:...|.|                               |....||
Zfish   146 IDSV------GEGNDVSSKLQELCIDG-------------------------------GVDHQSA 173

  Fly   264 AIGAEIEGPETDLVLVDTPKKPERDLIALLKHTSGALSQIKDLTLKSYYIAVDVENKTQAEEYEN 328
                    |::|.|.|                            .|.:||:|        .|..:
Zfish   174 --------PQSDNVPV----------------------------FKPFYISV--------MEETD 194

  Fly   329 FGGALSMDHIRDLYQEYKLRDQ---NPGQSPTGGASGPGEQGDENESYEKALPAHGDLVFHNFIT 390
            ..|...:||..:|.:||:.|::   ...||        .|.|:..|.|||....|||..|..|:.
Zfish   195 LDGFQDVDHENELLREYEERERVSVEEIQS--------CESGEAREEYEKGTAKHGDDTFTGFMK 251

  Fly   391 TIHQNPGQLLRYSRDTIPLLV----APFTEPLPKCQNCRGETICEVQLLPTLIPKLRFQVNGCNA 451
            .|...|.|:||||.:..||.:    ...::.:|.|.:|....:.|.||:|.|:..|.........
Zfish   252 KISLCPEQVLRYSWNGSPLFIMKPPCNASQMVPSCSHCGSLRVFEFQLMPALVSLLGSADTNSEI 316

  Fly   452 PIEFGNVLVFTCLKSCWDTPDLMRYEHIV 480
            .:|||.|||:||..|||.:...:..|..:
Zfish   317 SLEFGTVLVYTCRNSCWKSGSTVPVEEFL 345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trus	NP_650205.1	PDCD2_C	371..482	CDD:282100	39/114 (34%)
pdcd2l	NP_956517.1	PDCD2_C	232..348	CDD:282100	39/114 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579306
Domainoid	1	1.000	84	1.000	Domainoid score	I8252
eggNOG	1	0.900	-	-		E1_KOG2061
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41861
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54449
OrthoDB	1	1.010	-	-		D1181470at2759
OrthoFinder	1	1.000	-	-		FOG0001596
OrthoInspector	1	1.000	-	-		oto38849
orthoMCL	1	0.900	-	-		OOG6_103161
Panther	1	1.100	-	-	LDO	PTHR46421
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1686
SonicParanoid	1	1.000	-	-		X4734
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.750