DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18549 and srw-29

DIOPT Version :9

Sequence 1:	NP_650203.3	Gene:	CG18549 / 41538	FlyBaseID:	FBgn0038053	Length:	436	Species:	Drosophila melanogaster
Sequence 2:	NP_507151.2	Gene:	srw-29 / 184965	WormBaseID:	WBGene00005776	Length:	361	Species:	Caenorhabditis elegans

Alignment Length:	229	Identity:	47/229 - (20%)
Similarity:	78/229 - (34%)	Gaps:	49/229 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 RVAMVVGALTYTAFMITFMFPSTVLLYVGSAVLGLGASITWTGQGTYLARCSESST-ISRNSGVF 138
            |:..|..:|.....:..|.||...|.|....    .|.:......|...|.||:|| ||.:
Worm   149 RLTQVEYSLKIIITITMFAFPIWALYYTKLC----SAKVPGWMPFTNCHRFSENSTKISID---- 205

  Fly   139 WALLQCSMFIGNLFVYYQFQDKTRIDKETRNLVIGVLTVIAVLGIVFLAALRFMADNAEHDNELE 203
               .|.:...|:..:|   :....|:.....|:..::..|..:|:|               .:|:
Worm   206 ---FQINRLFGSTLIY---EIDLLIEGVLLELIPSIILPITTIGLV---------------KDLK 249

  Fly   204 QKHTGCGQAIYALKSAGQLFLTKKMLLLSLAFFYTGLE--LSFFSGVFGS----AIGFTTKIAET 262
            :..........:.||...|...|.:..::::|.:|...  |.:..|:|.:    .:....|.|..
Worm   250 EAQKNSMSIKSSTKSHDTLRSIKLVTFMTISFLFTTTPHGLMYVIGMFNTDKPGLVMIILKFARL 314

  Fly   263 PKEIVGLVG-----ICI--------GAGEVFGGG 283
            ...:..|.|     ||.        .|.||||.|
Worm   315 FTFLTTLNGIAHILICYLMSTQYRNTANEVFGEG 348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18549	NP_650203.3	MFS_MFSD11	8..423	CDD:340965	47/229 (21%)
srw-29	NP_507151.2	7TM_GPCR_Srw	36..346	CDD:370978	44/225 (20%)
		TM helix 2	66..92	CDD:341315
		TM helix 3	110..140	CDD:341315
		TM helix 4	154..185	CDD:341315	7/34 (21%)
		TM helix 5	218..243	CDD:341315	4/27 (15%)
		TM helix 6	265..295	CDD:341315	5/29 (17%)
		TM helix 7	309..334	CDD:341315	6/24 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3098
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900