DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Desat2 and SCD

DIOPT Version :9

Sequence 1:	NP_650201.1	Gene:	Desat2 / 41536	FlyBaseID:	FBgn0043043	Length:	361	Species:	Drosophila melanogaster
Sequence 2:	NP_005054.3	Gene:	SCD / 6319	HGNCID:	10571	Length:	359	Species:	Homo sapiens

Alignment Length:	338	Identity:	176/338 - (52%)
Similarity:	232/338 - (68%)	Gaps:	4/338 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 APYSRIYHQDKSSRETGVLF-EDDAQ-TVDGDLTTDRFQLKRAEKRRLPLVWRNIILFALVHLAA 64
            ||.||:........||..|: |||.: .:..|:....::.|.....::..|||||||.:|:||.|
Human    22 APPSRVLQNGGDKLETMPLYLEDDIRPDIKDDIYDPTYKDKEGPSPKVEYVWRNIILMSLLHLGA 86

  Fly    65 LYGLHSIFTRAKLATTLFAAGLYIIGMLGVTAGAHRLWAHRTYKAKWPLRLLLVIFNTIAFQDAV 129
            |||: ::....|..|.|:....|.:..||:||||||||:||:|||:.||||.|:|.||:|||:.|
Human    87 LYGI-TLIPTCKFYTWLWGVFYYFVSALGITAGAHRLWSHRSYKARLPLRLFLIIANTMAFQNDV 150

  Fly   130 YHWARDHRVHHKYSETDADPHNATRGFFFSHVGWLLCKKHPDIKEKGRGLDLSDLRADPILMFQR 194
            |.||||||.|||:|||.|||||:.||||||||||||.:|||.:||||..||||||.|:.::||||
Human   151 YEWARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGSTLDLSDLEAEKLVMFQR 215

  Fly   195 KHYYILMPLACFVLPTVIPMVYWNETLASSWFVATMFRWCFQLNMTWLVNSAAHKFGNRPYDKTM 259
            ::|...:.:.||:|||::|..:|.||..:|.||||..|:...||.|||||||||.||.|||||.:
Human   216 RYYKPGLLMMCFILPTLVPWYFWGETFQNSVFVATFLRYAVVLNATWLVNSAAHLFGYRPYDKNI 280

  Fly   260 NPTQNAFVSAFTFGEGWHNYHHAFPWDYKTAEWGCYSLNITTAFIDLFAKIGWAYDLKTVAPDVI 324
            :|.:|..||....|||:|||||:||:||..:|:. :.:|.||.|||..|.:|.|||.|.|:...|
Human   281 SPRENILVSLGAVGEGFHNYHHSFPYDYSASEYR-WHINFTTFFIDCMAALGLAYDRKKVSKAAI 344

  Fly   325 QRRVLRTGDGSHE 337
            ..|:.|||||:::
Human   345 LARIKRTGDGNYK 357

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Desat2	NP_650201.1	Delta9-FADS-like	76..317	CDD:239582	141/240 (59%)
Desat2	NP_650201.1	FA_desaturase	81..284	CDD:278890	123/202 (61%)
SCD	NP_005054.3	Delta9-FADS-like	100..337	CDD:239582	140/237 (59%)
		FA_desaturase	102..306	CDD:278890	124/203 (61%)
		Histidine box-1. /evidence=ECO:0000305	120..125		4/4 (100%)
		Histidine box-2. /evidence=ECO:0000305	157..161		2/3 (67%)
		Histidine box-3. /evidence=ECO:0000305	298..302		3/3 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	294	1.000	Domainoid score	I1492
eggNOG	1	0.900	-	-		E1_COG1398
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H74538
Inparanoid	1	1.050	369	1.000	Inparanoid score	I2141
Isobase	1	0.950	-	0.837287	Normalized mean entropy	S1208
OMA	1	1.010	-	-		QHG63267
OrthoDB	1	1.010	-	-		D296120at33208
OrthoFinder	1	1.000	-	-		FOG0000495
OrthoInspector	1	1.000	-	-		mtm8474
orthoMCL	1	0.900	-	-		OOG6_100468
Panther	1	1.100	-	-	O	PTHR11351
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R16
SonicParanoid	1	1.000	-	-		X207
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.820