Protein Alignment Srlp and CDYL

DIOPT Version :10

• Sequence 1: NP_650199.1
• Gene: Srlp / 41533
• FlyBaseID: FBgn0038049
• Length: 378
• Species: Drosophila melanogaster
• Sequence 2: NP_001355054.1
• Gene: CDYL / 9425
• HGNCID: 1811
• Length: 598
• Species: Homo sapiens
• Alignment Length: 239
• Identity: 63/239 - (26%)
• Similarity: 110/239 - (46%)
• Gaps: 20/239 - (8%)

  Fly    20 TAASRTFSSTKALHKDP-------ATQEAEAA-PPKNILVEKDKNITLIGIN-RPQQRNAIDSLT 75
            ||:.|.|...:  ...|       :.::.|:| ..::|:|.|....|.|.:: :..:.|:::...
Human   309 TASKRKFIDDR--RDQPFDKRLRFSVRQTESAYRYRDIVVRKQDGFTHILLSTKSSENNSLNPEV 371

  Fly    76 ASQLCDAFANFEADDTSPVAVLYGVGGSFCSGFDILEI---STDEKEEISVDILMRPEGSVGPTR 137
            ..::..|.:...||| |.:.:|..||..||.|.|.:..   .||:::..|..:.......|. |.
Human   372 MREVQSALSTAAADD-SKLVLLSAVGSVFCCGLDFIYFIRRLTDDRKRESTKMAEAIRNFVN-TF 434

  Fly   138 RQIKKPVVCGINGYCIANGLELALMCDLRVMEESAVLGFFNRRFGVPMLDAGTIRLPAMIGLSRA 202
            .|.|||::..:||..|..|..:..:||:....|.|........||.......|:..|.::|.:.|
Human   435 IQFKKPIIVAVNGPAIGLGASILPLCDVVWANEKAWFQTPYTTFGQSPDGCSTVMFPKIMGGASA 499

  Fly   203 LDLILTGRPVGSQEAHDIGLVNRIVPTGTALGNAL----ELATC 242
            .:::|:||.:.:|||...|||:::...||.....:    |||:|
Human   500 NEMLLSGRKLTAQEACGKGLVSQVFWPGTFTQEVMVRIKELASC 543

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Srlp	NP_650199.1	crotonase-like	49..259	CDD:474030	56/202 (28%)
CDYL	NP_001355054.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..76
		Interaction with EZH2. /evidence=ECO:0000269|PubMed:22009739	61..309		63/239 (26%)
		CD_CDY	62..111	CDD:349284
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	112..149
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	204..226
		crotonase-like	344..540	CDD:119339	52/197 (26%)
		Acetyl-CoA-binding domain. /evidence=ECO:0000255	362..594		51/184 (28%)