DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Srlp and hadhab

DIOPT Version :9

Sequence 1:	NP_650199.1	Gene:	Srlp / 41533	FlyBaseID:	FBgn0038049	Length:	378	Species:	Drosophila melanogaster
Sequence 2:	NP_001082906.1	Gene:	hadhab / 793834	ZFINID:	ZDB-GENE-041111-204	Length:	763	Species:	Danio rerio

Alignment Length:	328	Identity:	81/328 - (24%)
Similarity:	141/328 - (42%)	Gaps:	69/328 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 VGQQARFTAASRTF--SSTKALHKDPATQEAEAAPPKNILVEKDKNITLIGINRPQQRNAIDSLT 75
            :|..:|.|....|.  ..|:...|..|...|..    ::..|...::.::.:|.|..:  :::|:
Zfish     7 LGSLSRLTTRRYTLFPGVTRRTFKFAACMMART----HVSYEVKGDVAVVRMNDPTAK--VNTLS 65

  Fly    76 ASQ-------LCDAFANFEADDTSPVAVLYGVGGSFCSGFDILEI-STDEKEEISVDILMRPEGS 132
            ...       :.:.:.|   .....|.::....|.|.:|.||..| :....||::.   :..||
Zfish    66 VQMQKDMTEVMDEVWGN---SAVQSVVLISSKPGCFIAGADISMIKACKTAEEVTG---LSQEG- 123

  Fly   133 VGPTRRQIK------KPVVCGINGYCIANGLELALMCDLRVMEES--AVLGFFNRRFGVPMLDAG 189
                :|..:      ||:|..|||.|:..|||.|:.|..|:..:|  .|||......|:.....|
Zfish   124 ----QRMFEKIEKSPKPIVAAINGSCLGGGLEFAIACQYRIATKSKKTVLGCPEVMLGLLPGAGG 184

  Fly   190 TIRLPAMIGLSRALDLILTGRPVGSQEAHDIGLVNRIVPT-GTALGN------------ALELAT 241
            |.|||.|:||..|.|::||||.:.:.:|..:|||:::|.| |..|.:            |:|.|.
Zfish   185 TQRLPKMLGLPSAFDVMLTGRSIRADKAKKMGLVHQLVDTLGPGLKSPEERTIEYLEEVAVEAAR 249

  Fly   242 CLAK----------FPQRALIHDRNSVYSSTFETSTFHQAVQNEVMFTSR-------EIIEDMQN 289
            .||:          :.|:.    ::.|.|..|.....:..|:.:||..::       :|||.::.
Zfish   250 GLAQKKITLTKEKGWMQKI----QDYVMSYPFVRQQIYNTVEKKVMKQTKGLYPAPLKIIESVKA 310

  Fly   290 GIK 292
            |::
Zfish   311 GVE 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Srlp	NP_650199.1	crotonase-like	49..259	CDD:304874	63/248 (25%)
hadhab	NP_001082906.1	fa_ox_alpha_mit	27..762	CDD:131494	76/308 (25%)
		crotonase-like	41..251	CDD:119339	60/222 (27%)
		3HCDH_N	363..541	CDD:280833
		3HCDH	544..639	CDD:279114
		3HCDH	676..>750	CDD:279114
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810