DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Srlp and Eci2

DIOPT Version :9

Sequence 1:	NP_650199.1	Gene:	Srlp / 41533	FlyBaseID:	FBgn0038049	Length:	378	Species:	Drosophila melanogaster
Sequence 2:	NP_001006967.1	Gene:	Eci2 / 291075	RGDID:	1359427	Length:	391	Species:	Rattus norvegicus

Alignment Length:	307	Identity:	78/307 - (25%)
Similarity:	123/307 - (40%)	Gaps:	28/307 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 GLLAQQVGQQARFTAASRTFSSTKALHKDPATQEAEAAPPKNILVEKDKNITLIGINRPQQRNAI 71
            |.|.::..:|......|...||::|..:.....:.:|...|.|||..:..||.|..|||.::|||
  Rat    98 GSLPKETARQNYVDLVSSLSSSSEASSQGKGGADGKAQESKGILVTSEGGITKITFNRPSKKNAI 162

  Fly    72 DSLTASQLCDAFANFEADDTSPVAVLYGVGGSFCSGFDILEISTD----EKEEISVDILMRPEGS 132
            .......:..|..|...||| .:.|..|.|..:.||.|:...::.    |:......|::|   .
  Rat   163 TFQMYQDIILALKNASTDDT-VITVFTGAGDYYSSGNDLTNFTSASGGMEEAANKGAIVLR---E 223

  Fly   133 VGPTRRQIKKPVVCGINGYCIANGLELALMCDLRVMEESAVLGFFNRRFGVPMLDAG-------T 190
            ...|.....||:|..:||..:...:.|..:.|       ||.......|..|....|       :
  Rat   224 FVNTFIDFPKPLVAVVNGPAVGISVTLLGLFD-------AVYASDRATFHTPFSHLGQSPEACSS 281

  Fly   191 IRLPAMIGLSRALDLILTGRPVGSQEAHDIGLVNRIVPTGTALGNALELATCLAKFPQRALIHDR 255
            ...|.|:|.::|.:::|.|:.:.::||...|||..:.|..|............||.|..::...:
  Rat   282 YTFPKMMGSAKAAEMLLFGKKLTAREAWAQGLVTEVFPESTFETEVWTRLKTYAKLPPNSMRISK 346

  Fly   256 NSVYSSTFETSTFHQAVQNEVMFT--SREIIEDMQNGIKWFNQTFKP 300
            ..:..:  |....| ||..|...|  :|.:.|:..|.|..| .|.||
  Rat   347 ELIRKN--EKEKLH-AVNEEECTTLRARWLSEECINAIMSF-VTRKP 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Srlp	NP_650199.1	crotonase-like	49..259	CDD:304874	55/220 (25%)
Eci2	NP_001006967.1	ACBP	38..113	CDD:279259	3/14 (21%)
		Acyl-CoA binding. /evidence=ECO:0000250	64..68
		crotonase-like	134..389	CDD:304874	69/269 (26%)
		ECH-like	149..319		46/180 (26%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q05871	196..200		2/3 (67%)
		Microbody targeting signal. /evidence=ECO:0000255	389..391		1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810