DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Srlp and Cdyl

DIOPT Version :9

Sequence 1:	NP_650199.1	Gene:	Srlp / 41533	FlyBaseID:	FBgn0038049	Length:	378	Species:	Drosophila melanogaster
Sequence 2:	NP_034011.1	Gene:	Cdyl / 12593	MGIID:	1339956	Length:	593	Species:	Mus musculus

Alignment Length:	204	Identity:	55/204 - (26%)
Similarity:	96/204 - (47%)	Gaps:	10/204 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 KNILVEKDKNITLIGIN-RPQQRNAIDSLTASQLCDAFANFEADDTSPVAVLYGVGGSFCSGFDI 110
            ::|:|.|....|.|.:: :..:.|:::.....::..|.:...||| |.:.:|..||..||.|.|.
Mouse   337 RDIVVRKQDGFTHILLSTKSSENNSLNPEVMKEVQSALSTAAADD-SKLVLLSAVGSVFCCGLDF 400

  Fly   111 LEI---STDEKEEISVDILMRPEGSVGPTRRQIKKPVVCGINGYCIANGLELALMCDLRVMEESA 172
            :..   .||:::..|..:.......|. |..|.|||::..:||..|..|..:..:||:....|.|
Mouse   401 IYFIRRLTDDRKRESTKMADAIRNFVN-TFIQFKKPIIVAVNGPAIGLGASILPLCDVVWANEKA 464

  Fly   173 VLGFFNRRFGVPMLDAGTIRLPAMIGLSRALDLILTGRPVGSQEAHDIGLVNRIVPTGTALGNAL 237
            ........||.......|:..|.::|.:.|.:::.:||.:.:|||...|||:::...||.....:
Mouse   465 WFQTPYTTFGQSPDGCSTVMFPKIMGGASANEMLFSGRKLTAQEACGKGLVSQVFWPGTFTQEVM 529

  Fly   238 ----ELATC 242
                |||:|
Mouse   530 VRIKELASC 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Srlp	NP_650199.1	crotonase-like	49..259	CDD:304874	55/202 (27%)
Cdyl	NP_034011.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30
		CHROMO	55..109	CDD:214605
		Interaction with EZH2. /evidence=ECO:0000250\|UniProtKB:Q9Y232	56..304
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	110..158
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	200..223
		crotonase-like	339..535	CDD:119339	51/197 (26%)
		Acetyl-CoA-binding domain. /evidence=ECO:0000255	357..589		50/184 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810