DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aos1 and Nae1

DIOPT Version :9

Sequence 1:	NP_650198.1	Gene:	Aos1 / 41532	FlyBaseID:	FBgn0029512	Length:	337	Species:	Drosophila melanogaster
Sequence 2:	NP_114461.3	Gene:	Nae1 / 84019	RGDID:	619945	Length:	534	Species:	Rattus norvegicus

Alignment Length:	259	Identity:	69/259 - (26%)
Similarity:	118/259 - (45%)	Gaps:	29/259 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 ENELYDRQIRLWGLESQKRLRTAKILIAGLCGLGAEITKNIILSGVNSVKLLDDKDVTEEDFCSQ 82
            :.:.||||:||||...|:.|.:|.:.:......|.||.||::|.|:.|..::|...|:.||..:.
  Rat     9 KEQKYDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPGIGSFTIIDGNQVSGEDVGNN 73

  Fly    83 FLVPRESLNTNRAEASLTRARALNPMVD---ISADREPLKEKTSEFFGQFDVVVVNGATNEELLR 144
            |.:.:.|:..|||:|::...:.||..|.   :....|.|.:....||.:|.:||........|||
  Rat    74 FFLQKCSIGKNRAQAAMEFLQELNSDVSGSFVEESPENLLDNDPSFFCRFTIVVATQLLESTLLR 138

  Fly   145 IDTICRDLGVKFIATDVWGTFGFYFASLQKHSYVEDVIKHKVVANSEKKKKYETVSI----PTQR 205
            :..:..:..:..:....:|..|          |:..:||...|..|......|.:.:    |..|
  Rat   139 LADVLWNSQIPLLICRTYGLVG----------YMRIIIKEHPVIESHPDNALEDLRLDKPFPELR 193

  Fly   206 DVDYPGYSAWLDFDVTEPSYLRKLKRNGPGVLLLS--VLQKFRTTHKRDP-SYKTREADLELLR 266
            : .:..|    |.|..|    :|...:.|.:::::  :.|.:..|:.|.| |||.:|...||:|
  Rat   194 E-HFQSY----DLDHME----KKDHSHTPWIVIIAKYLAQWYSETNGRIPKSYKEKEDFRELIR 248

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aos1	NP_650198.1	Aos1_SUMO	19..>172	CDD:238769	44/155 (28%)
Aos1	NP_650198.1	ThiF	22..>167	CDD:279270	43/147 (29%)
Nae1	NP_114461.3	ThiF	9..>193	CDD:223552	51/193 (26%)
		APPBP1_RUB	11..532	CDD:238770	69/257 (27%)
		Interaction with UBA3. /evidence=ECO:0000250	331..344
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910