Protein Alignment Aos1 and UBA5

DIOPT Version :10

• Sequence 1: NP_650198.1
• Gene: Aos1 / 41532
• FlyBaseID: FBgn0029512
• Length: 337
• Species: Drosophila melanogaster
• Sequence 2: NP_079094.1
• Gene: UBA5 / 79876
• HGNCID: 23230
• Length: 404
• Species: Homo sapiens
• Alignment Length: 318
• Identity: 68/318 - (21%)
• Similarity: 113/318 - (35%)
• Gaps: 82/318 - (25%)

  Fly    12 VELTEAENELYDRQ-------IRLWGLESQ-KRLRTAKILIAGLCGLGAEITKNIILSGVNSVKL 68
            |.:.:..:|:.|..       ::..|:.|. :::||..:.|.|:.|:|:...:.:...|:..:.|
Human    38 VRIEKMSSEVVDSNPYSRLMALKRMGIVSDYEKIRTFAVAIVGVGGVGSVTAEMLTRCGIGKLLL 102

  Fly    69 LDDKDVTEEDFCSQFLVPRESLNTNRAEASLTRARALNPMVDISADREPLKEKTSEFFGQFDVVV 133
            .|...|...:....|..|.:: ..::.:|:....|.:||  |:..:.......|.|.|..|...:
Human   103 FDYDKVELANMNRLFFQPHQA-GLSKVQAAEHTLRNINP--DVLFEVHNYNITTVENFQHFMDRI 164

  Fly   134 VNGATN---------------EELLRIDTICRDLGVKFIATDVWGTFGFYFASLQKHSYVEDVIK 183
            .||...               |..:.|:|.|.:||      ..|...|....::..|  ::.:|.
Human   165 SNGGLEEGKPVDLVLSCVDNFEARMTINTACNELG------QTWMESGVSENAVSGH--IQLIIP 221

  Fly   184 HK-----------VVAN-SEKKKKYETV---SIPTQRDV--------------------DYPGYS 213
            .:           |.|| .||..|.|.|   |:||...|                    .|.||:
Human   222 GESACFACAPPLVVAANIDEKTLKREGVCAASLPTTMGVVAGILVQNVLKFLLNFGTVSFYLGYN 286

  Fly   214 AWLDFDVTEPSYLRKLKRNGPGVLLLSVLQKFRTTHKRDPSYKTREADLELLRGIRDE 271
            |..||..|     ..:|.| |..       ..|...|:...||.:.|.|.....|::|
Human   287 AMQDFFPT-----MSMKPN-PQC-------DDRNCRKQQEEYKKKVAALPKQEVIQEE 331

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Aos1	NP_650198.1	Aos1_SUMO	19..>172	CDD:238769	35/175 (20%)
UBA5	NP_079094.1	ThiF_MoeB_HesA_family	52..297	CDD:238386	54/260 (21%)
		UFM1-interacting sequence (UIS). /evidence=ECO:0000269|PubMed:26929408, ECO:0000269|PubMed:27653677	334..346
		Linker. /evidence=ECO:0000269|PubMed:34588452	347..377
		UFC1-binding sequence (UFC). /evidence=ECO:0000269|PubMed:34588452	389..404