DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aos1 and UBA5

DIOPT Version :9

Sequence 1:	NP_650198.1	Gene:	Aos1 / 41532	FlyBaseID:	FBgn0029512	Length:	337	Species:	Drosophila melanogaster
Sequence 2:	NP_079094.1	Gene:	UBA5 / 79876	HGNCID:	23230	Length:	404	Species:	Homo sapiens

Alignment Length:	318	Identity:	68/318 - (21%)
Similarity:	113/318 - (35%)	Gaps:	82/318 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 VELTEAENELYDRQ-------IRLWGLESQ-KRLRTAKILIAGLCGLGAEITKNIILSGVNSVKL 68
            |.:.:..:|:.|..       ::..|:.|. :::||..:.|.|:.|:|:...:.:...|:..:.|
Human    38 VRIEKMSSEVVDSNPYSRLMALKRMGIVSDYEKIRTFAVAIVGVGGVGSVTAEMLTRCGIGKLLL 102

  Fly    69 LDDKDVTEEDFCSQFLVPRESLNTNRAEASLTRARALNPMVDISADREPLKEKTSEFFGQFDVVV 133
            .|...|...:....|..|.:: ..::.:|:....|.:||  |:..:.......|.|.|..|...:
Human   103 FDYDKVELANMNRLFFQPHQA-GLSKVQAAEHTLRNINP--DVLFEVHNYNITTVENFQHFMDRI 164

  Fly   134 VNGATN---------------EELLRIDTICRDLGVKFIATDVWGTFGFYFASLQKHSYVEDVIK 183
            .||...               |..:.|:|.|.:||      ..|...|....::..|  ::.:|.
Human   165 SNGGLEEGKPVDLVLSCVDNFEARMTINTACNELG------QTWMESGVSENAVSGH--IQLIIP 221

  Fly   184 HK-----------VVAN-SEKKKKYETV---SIPTQRDV--------------------DYPGYS 213
            .:           |.|| .||..|.|.|   |:||...|                    .|.||:
Human   222 GESACFACAPPLVVAANIDEKTLKREGVCAASLPTTMGVVAGILVQNVLKFLLNFGTVSFYLGYN 286

  Fly   214 AWLDFDVTEPSYLRKLKRNGPGVLLLSVLQKFRTTHKRDPSYKTREADLELLRGIRDE 271
            |..||..|     ..:|.| |..       ..|...|:...||.:.|.|.....|::|
Human   287 AMQDFFPT-----MSMKPN-PQC-------DDRNCRKQQEEYKKKVAALPKQEVIQEE 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aos1	NP_650198.1	Aos1_SUMO	19..>172	CDD:238769	35/175 (20%)
Aos1	NP_650198.1	ThiF	22..>167	CDD:279270	33/167 (20%)
UBA5	NP_079094.1	ThiF_MoeB_HesA_family	52..297	CDD:238386	54/260 (21%)
UBA5	NP_079094.1	UFM1-interacting sequence (UIS). /evidence=ECO:0000269\|PubMed:26929408, ECO:0000269\|PubMed:27653677	334..346
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900