DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aos1 and nae1

DIOPT Version :9

Sequence 1:	NP_650198.1	Gene:	Aos1 / 41532	FlyBaseID:	FBgn0029512	Length:	337	Species:	Drosophila melanogaster
Sequence 2:	NP_956793.1	Gene:	nae1 / 573336	ZFINID:	ZDB-GENE-040426-1552	Length:	533	Species:	Danio rerio

Alignment Length:	335	Identity:	80/335 - (23%)
Similarity:	141/335 - (42%)	Gaps:	72/335 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 AENELYDRQIRLWGLESQKRLRTAKILIAGLCGLGAEITKNIILSGVNSVKLLDDKDVTEEDFCS 81
            ::.:.||||:||||...|:.|..|.:.:......|.||.||::|.|:.:..::|...|:.||..:
Zfish     7 SKEQRYDRQLRLWGDHGQEALENAHVCLINATASGTEILKNLVLPGIGAFTIVDGHKVSGEDVGN 71

  Fly    82 QFLVPRESLNTNRAEASLTRARALNP-----MVDISADREPLKEKTSEFFGQFDVVVVNGATNEE 141
            .|.:...::..|||:|:....:.||.     .|:.|.|:  |.:...|||.:|.:|:........
Zfish    72 NFFLSSSAIGKNRAQAATELLQELNSDVSGNFVEESPDK--LLDNDCEFFHRFSLVIAVQLPEST 134

  Fly   142 LLRIDTICRDLGVKFIATDVWGTFGFYFASLQKHSYVEDVIKHKVVA---------NSEKKKKYE 197
            .|.:..:..:.||.|:....:|..|:....:::|:.||   .|...|         .:|.|:..|
Zfish   135 CLGLGAVLWEAGVPFLVCRTYGLIGYMRLIVKEHTVVE---SHPDNALEDLRLDQPFTELKRHVE 196

  Fly   198 TVSIPTQRDVDYPGYSAWLDFDVTEPSYLRK-LKRNGPGVLLLSVLQKFRTTHKRDPSYKTREAD 261
            :..:......|: .::.|:   :....||.| ...|.      |.|.|         :||.:||.
Zfish   197 SYDLDNMEKKDH-SHTPWI---IVVARYLEKWYNENN------SQLPK---------NYKEKEAF 242

  Fly   262 LELLR---------GIRDELLPNSILGDEALGLIFAQISPAVAVVGGVVAQEVIKVVTKLEAPHR 317
            .:|||         |:.||  .|.   :||:..:...::|                 ||:.:..:
Zfish   243 RQLLREGILKNENGGLEDE--ENF---EEAIKNVNTALNP-----------------TKISSGTQ 285

  Fly   318 NLFVFDPETC 327
            :  :|:.|.|
Zfish   286 D--IFNAEQC 293

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aos1	NP_650198.1	Aos1_SUMO	19..>172	CDD:238769	44/157 (28%)
Aos1	NP_650198.1	ThiF	22..>167	CDD:279270	43/149 (29%)
nae1	NP_956793.1	ThiF	6..>164	CDD:223552	44/158 (28%)
		APPBP1_RUB	10..531	CDD:238770	80/332 (24%)
		Interaction with uba3. /evidence=ECO:0000250	330..343
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1600
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840