DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aos1 and UBA6

DIOPT Version :9

Sequence 1:	NP_650198.1	Gene:	Aos1 / 41532	FlyBaseID:	FBgn0029512	Length:	337	Species:	Drosophila melanogaster
Sequence 2:	NP_060697.4	Gene:	UBA6 / 55236	HGNCID:	25581	Length:	1052	Species:	Homo sapiens

Alignment Length:	415	Identity:	99/415 - (23%)
Similarity:	159/415 - (38%)	Gaps:	105/415 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SETAVELTEAENELYDRQIRLWGLESQKRLRTAKILIAGLCGLGAEITKNIILSGVNSVKLLDDK 72
            |..:||:.:|   ||.||..:.|..:.:::..:.:.::|:.|||.||.||::|:|:.:|.:.|.:
Human    33 STASVEIDDA---LYSRQRYVLGDTAMQKMAKSHVFLSGMGGLGLEIAKNLVLAGIKAVTIHDTE 94

  Fly    73 DVTEEDFCSQFLVPRESL--NTNRAEASLTRARALNPMVDISADREPLKEKTS-EFFGQFDVVVV 134
            .....|..:.|.:..:.:  ..|||||.|.....|||.|.:::...|..|.|. .|..::..||:
Human    95 KCQAWDLGTNFFLSEDDVVNKRNRAEAVLKHIAELNPYVHVTSSSVPFNETTDLSFLDKYQCVVL 159

  Fly   135 NGATNEELLRIDTICRDL--GVKFIATDVWG-------TFGFYFASLQ------KHSYVEDVIKH 184
            .........:|:..||..  .:|||:.||.|       .||..|..|.      |..::.::.:.
Human   160 TEMKLPLQKKINDFCRSQCPPIKFISADVHGIWSRLFCDFGDEFEVLDTTGEEPKEIFISNITQA 224

  Fly   185 K---VVANSEKKKKYETVSIPTQRDVD----------------------------YPGYSAWLDF 218
            .   |........|.||....|.|:::                            .|.....:..
Human   225 NPGIVTCLENHPHKLETGQFLTFREINGMTGLNGSIQQITVISPFSFSIGDTTELEPYLHGGIAV 289

  Fly   219 DVTEP------SYLRKLKRNGPGVLLLS---------------VLQKFRTTHKRDPSYKTREADL 262
            .|..|      |..|:||.  |..|::.               .|.:|:..:.|.|:...::...
Human   290 QVKTPKTVFFESLERQLKH--PKCLIVDFSNPEAPLEIHTAMLALDQFQEKYSRKPNVGCQQDSE 352

  Fly   263 ELLRGIRDELLPNSI-----------------LGDEALGLIFAQISPAVAVVGGVVAQEVIKVVT 310
            |||:      |..||                 |...|.|.    :||..|.||||.:|||:|.||
Human   353 ELLK------LATSISETLEEKPDVNADIVHWLSWTAQGF----LSPLAAAVGGVASQEVLKAVT 407

  Fly   311 KLEAPHRNLFVFDPETCAGYVEAIG 335
            ...:|.......:   .|..||::|
Human   408 GKFSPLCQWLYLE---AADIVESLG 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aos1	NP_650198.1	Aos1_SUMO	19..>172	CDD:238769	47/164 (29%)
Aos1	NP_650198.1	ThiF	22..>167	CDD:279270	44/156 (28%)
UBA6	NP_060697.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Ube1	38..1046	CDD:273603	97/410 (24%)
		Ube1_repeat1	43..432	CDD:238768	95/402 (24%)
		E1_4HB	299..361	CDD:292809	14/69 (20%)
		Ube1_repeat2	462..1005	CDD:238767
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810