DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aos1 and uba2

DIOPT Version :9

Sequence 1:	NP_650198.1	Gene:	Aos1 / 41532	FlyBaseID:	FBgn0029512	Length:	337	Species:	Drosophila melanogaster
Sequence 2:	NP_001017091.1	Gene:	uba2 / 549845	XenbaseID:	XB-GENE-977709	Length:	641	Species:	Xenopus tropicalis

Alignment Length:	458	Identity:	88/458 - (19%)
Similarity:	154/458 - (33%)	Gaps:	178/458 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 ESQKRLRTAKILIAGLCGLGAEITKNIILSGVNSVKLLDDKDVTEEDFCSQFLVPRESLNTNRAE 96
            |..:.:.|:::|:.|..|:|.|:.||::|:|..::.::|...:...:...|||..::.:..::|:
Frog    10 ELAEAVSTSRLLVVGAGGIGCELLKNLVLTGFINLDVIDLDTIDVSNLNRQFLFQKKHVGRSKAQ 74

  Fly    97 ASLTRARALNPMVDISADREPL--KEKTSEFFGQFDVVV----VNGATNEELLRIDTICRDLGVK 155
            .:........|..:|:|..:.:  .:...|||.||.:|:    .|.|.|    .::.:|...|:.
Frog    75 VAKESVLQFCPEANITAYHDSIMNPDYNVEFFKQFTMVMNALDNNAARN----HVNRMCLAAGIP 135

  Fly   156 FIATDVWGTFGFYFASLQKHSYVEDVIKHKVVANSEKKKKYETVSIPTQRDVDYPG--------- 211
            .|.:   ||.| |...:       .|:|..|.      :.||....|||:  .:||
Frog   136 LIES---GTAG-YLGQV-------TVVKKGVT------ECYECQPKPTQK--TFPGCTIRNTPSE 181

  Fly   212 --------------------------------YSAW-------------LDFDVTEPSYLRKLKR 231
                                            .:||             :|.|:...|..:..|.
Frog   182 PIHCIVWAKYLFNQLFGEEDADQEVAPDIADPEAAWDPTQAAERANASNVDGDIKRVSTKQWAKS 246

  Fly   232 NGPGVLLL----------SVLQKFRTTHKRDP-------SYKTREADLEL-----LRGIRD---- 270
            .|...:.|          .:|...|...||.|       |...:|...|.     |:|::|
Frog   247 TGYDPIKLFNKLFRDDIKYLLTMDRLWRKRKPPVPLEWSSLHNKENCSETQNESSLQGLKDQKVL 311

  Fly   271 ------ELLPNSI------LGDEALGL------------------------IFA----------- 288
                  :|...|:      |.::..|.                        ||:
Frog   312 DVTSCAQLFSKSVETLREQLREKGNGAELVWDKDDPPAMDFVTAAANLRMHIFSMNMKSRFDVKS 376

  Fly   289 ---QISPAV----AVVGGVVAQEVIKVVT------------KLEAPHRNLFV---FDPETCAGYV 331
               .|.||:    ||:.|::..|.:|:::            |...|.:.|.|   .||...:.||
Frog   377 MAGNIIPAIATTNAVISGLIVLEGLKILSGNTEQCRTVFLNKQPNPRKKLLVPCSLDPPNPSCYV 441

  Fly   332 EAI 334
            .||
Frog   442 CAI 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aos1	NP_650198.1	Aos1_SUMO	19..>172	CDD:238769	35/145 (24%)
Aos1	NP_650198.1	ThiF	22..>167	CDD:279270	33/140 (24%)
uba2	NP_001017091.1	Uba2_SUMO	19..442	CDD:238766	83/445 (19%)
		UBA_e1_thiolCys	179..360	CDD:371150	23/180 (13%)
		UAE_UbL	450..536	CDD:373253
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	546..641
		UBA2_C	549..636	CDD:374424
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910