DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aos1 and uba3

DIOPT Version :9

Sequence 1:	NP_650198.1	Gene:	Aos1 / 41532	FlyBaseID:	FBgn0029512	Length:	337	Species:	Drosophila melanogaster
Sequence 2:	NP_998632.1	Gene:	uba3 / 406776	ZFINID:	ZDB-GENE-040426-2825	Length:	462	Species:	Danio rerio

Alignment Length:	340	Identity:	68/340 - (20%)
Similarity:	112/340 - (32%)	Gaps:	113/340 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 LRTAKILIAGLCGLGAEITKNIILSGVNSVKLLDDKDVTEEDFCSQFLVPRESLNTNRAEASLTR 101
            |.|.|||:.|..|||.|:.|::.|||...:.::|...:...:...|||...:.:...:||.:
Zfish    66 LDTCKILVIGAGGLGCELLKDLALSGFRHIHVVDMDTIDVSNLNRQFLFRPKDVGRPKAEVA--- 127

  Fly   102 ARALNPMVDISADREP----------LKEKTSEFFGQFDVVV-----------VNGATNEELLRI 145
                   .|...||.|          :::....|:.||.:||           :||.....|:..
Zfish   128 -------ADFVNDRVPGCSVVPHFKKIQDLDETFYRQFHIVVCGLDSVIARRWMNGMLLSLLIYE 185

  Fly   146 DTICRDLGVKFIATDVWGTFGFYFASLQKHSYVEDVIKHKVVANSEKKKKYETVSIPTQRDVDYP 210
            |.:.....:  |.....||.||                   ..|:.               |..|
Zfish   186 DGVLDPSSI--IPLIDGGTEGF-------------------KGNAR---------------VILP 214

  Fly   211 GYSAWLD--FDVTEP--------------------SYLRKL-----KRNGPGVLL-----LSVLQ 243
            |.:|.:|  .::..|                    .|:|.|     |..|.||:|     ..:..
Zfish   215 GMTACIDCTLELYPPQINFPMCTIASMPRLPEHCVEYVRMLLWPKEKPFGDGVVLDGDDPKHIQW 279

  Fly   244 KFRTTHKRDPSYKTREADLELLRGIRDELLPNSILGDEALGLIFAQISPAVAVVGGVVAQEVIKV 308
            .::.:.:|...:........|.:|:...::|              .::...||:....|.||.|:
Zfish   280 VYQKSLERAAEFNITGVTYRLTQGVVKRIIP--------------AVASTNAVIAAACATEVFKI 330

  Fly   309 VTKLEAPHRNLFVFD 323
            .|....|..|..||:
Zfish   331 ATSAYVPLNNYLVFN 345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aos1	NP_650198.1	Aos1_SUMO	19..>172	CDD:238769	38/155 (25%)
Aos1	NP_650198.1	ThiF	22..>167	CDD:279270	36/150 (24%)
uba3	NP_998632.1	Interaction with ube2m N-terminus. /evidence=ECO:0000250	52..69		1/2 (50%)
		ThiF	66..>240	CDD:279270	45/219 (21%)
		Uba3_RUB	70..367	CDD:238765	66/336 (20%)
		Interaction with ube2m N-terminus. /evidence=ECO:0000250	156..160		2/3 (67%)
		Interaction with ube2m N-terminus. /evidence=ECO:0000250	191..216		8/60 (13%)
		Interaction with nedd8. /evidence=ECO:0000250	226..228		0/1 (0%)
		Interaction with nae1. /evidence=ECO:0000250	241..247		0/5 (0%)
		Interaction with nae1. /evidence=ECO:0000250	291..294		0/2 (0%)
		Interaction with ube2m N-terminus. /evidence=ECO:0000250	330..337		1/6 (17%)
		Interaction with nedd8. /evidence=ECO:0000250	351..356
		Interaction with ube2m core domain. /evidence=ECO:0000250	367..462
		E2_bind	375..460	CDD:285976
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900