DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aos1 and Uba1

DIOPT Version :9

Sequence 1:	NP_650198.1	Gene:	Aos1 / 41532	FlyBaseID:	FBgn0029512	Length:	337	Species:	Drosophila melanogaster
Sequence 2:	NP_477310.2	Gene:	Uba1 / 35998	FlyBaseID:	FBgn0023143	Length:	1191	Species:	Drosophila melanogaster

Alignment Length:	404	Identity:	105/404 - (25%)
Similarity:	154/404 - (38%)	Gaps:	93/404 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 EAENELYDRQIRLWGLESQKRLRTAKILIAGLCGLGAEITKNIILSGVNSVKLLDDKDVTEEDFC 80
            :.:..||.||:.:.|.::.:|:..:.||::||.|||.||.||:||.||.|:.|.|.......|..
  Fly   194 DIDESLYSRQLYVLGHDAMRRMANSDILLSGLGGLGLEIAKNVILGGVKSITLHDTATCGLHDLS 258

  Fly    81 SQFLVPRESLNTNRAEASLTRARALNPMVDISADREPLKEKTSEFFGQFDVVVVNGATNEELLRI 145
            |||.:....:..||||||..:...||..|...:...||   |.||..:|.|||:..:..||..||
  Fly   259 SQFYLTEADIGKNRAEASCAQLAELNNYVRTVSHTGPL---TEEFLRKFRVVVLTNSDGEEQQRI 320

  Fly   146 DTICRDLGVKFIATDVWGTFGFYFASLQKHSYVED------------VIKHKV------------ 186
            .....:.|:..|..:..|.|...|....:...:.|            .|.|..
  Fly   321 AKFAHENGIALIIAETRGLFAKVFCDFGESFTIYDQDGTQPISTMIASITHDAQGVVTCLDETRH 385

  Fly   187 ------------------------------------VANSEKKKKYETVSIPTQRDVDYPGYSAW 215
                                                :.::.|..:|::..:.||  |..|...::
  Fly   386 GFNDGDYVTFSEVQGMQELNGCQPLKITVLGPYTFSIGDTSKFGEYKSGGVATQ--VKMPKTISF 448

  Fly   216 --LDFDVTEPSYLRK--LKRNGPGVL--LLSVLQKFRTTHKRDPSYKTREAD----LELLRGIRD 270
              |.....||.:|..  .|.:.|..|  ..:.|..:|..|.........|.|    ||::|...:
  Fly   449 KPLAQATEEPEFLISDFAKLDSPATLHVAFNALSCYRKAHNGALPRPWNEEDANSFLEVVRASSN 513

  Fly   271 ELLPNSILGDEALGLIFAQI-----SPAVAVVGGVVAQEVIKVVTKLEAPHRNLFVFDPETC--- 327
            ..:      ||.|.|.||:|     .|..|.|||:|||||:|..:....|......||...|
  Fly   514 AEV------DEKLVLQFAKICSGNTCPLDAAVGGIVAQEVLKACSGKFTPIYQWLYFDALECLPT 572

  Fly   328 AGYVEA----IGAK 337
            .|..||    :|::
  Fly   573 EGVEEADAQPVGSR 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aos1	NP_650198.1	Aos1_SUMO	19..>172	CDD:238769	55/152 (36%)
Aos1	NP_650198.1	ThiF	22..>167	CDD:279270	53/144 (37%)
Uba1	NP_477310.2	Ube1	194..1188	CDD:273603	105/404 (26%)
		Ube1_repeat1	199..574	CDD:238768	101/385 (26%)
		E1_4HB	447..510	CDD:292809	14/62 (23%)
		Ube1_repeat2	606..1144	CDD:238767
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446846
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0476
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10953
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840