DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aos1 and Uba1

DIOPT Version :9

Sequence 1:	NP_650198.1	Gene:	Aos1 / 41532	FlyBaseID:	FBgn0029512	Length:	337	Species:	Drosophila melanogaster
Sequence 2:	NP_001014102.1	Gene:	Uba1 / 314432	RGDID:	1359327	Length:	1058	Species:	Rattus norvegicus

Alignment Length:	404	Identity:	106/404 - (26%)
Similarity:	158/404 - (39%)	Gaps:	83/404 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 VVDMDTSETAVELTEA--ENELYDRQIRLWGLESQKRLRTAKILIAGLCGLGAEITKNIILSGVN 64
            |..:.|:..|...:||  :..||.||:.:.|.|:.|.|:|:.:|::||.|||.||.|||||.||.
  Rat    33 VSSVPTNGMAKNGSEADIDESLYSRQLYVLGHEAMKMLQTSSVLVSGLRGLGVEIAKNIILGGVK 97

  Fly    65 SVKLLDDKDVTEEDFCSQFLVPRESLNTNRAEASLTRARALNPMVDISADREPLKEKTSEFFGQF 129
            :|.|.|.......|..|||.:..|.:..||||.|..|...||..|.::|...||.|   :|...|
  Rat    98 AVTLHDQGTTQWADLSSQFYLREEDIGKNRAEVSQPRLAELNSYVPVTAYTGPLVE---DFLSGF 159

  Fly   130 DVVVVNGATNEELLRIDTICRDLGVKFIATDVWGTFGFYFASLQKHSYVED-------------V 181
            .|||:..:..||.||:...|...|:|.:..|..|.||..|....:...:.|             |
  Rat   160 QVVVLTNSPLEEQLRVGEFCHSRGIKLVVADTRGLFGQLFCDFGEEMVLTDSNGEQPLSAMVSMV 224

  Fly   182 IKHK---VVANSEKKKKYETVSIPTQRDV-------------------------DYPGYSAW--- 215
            .|..   |....|.:..:||....:..:|                         |...:|.:
  Rat   225 TKDNPGVVTCLDEARHGFETGDFVSFSEVQGMVQLNGCQPIEIKVLGPYTFSICDTSNFSDYIRG 289

  Fly   216 ----------------LDFDVTEPSYLRK--LKRNGPGVLLL--SVLQKFRTTHKRDPSYKTREA 260
                            |...:.||.::..  .|.:.|..|.:  ..|.:|...|.|.|..:..|.
  Rat   290 GIVSQVKVPKKISFKSLPASLAEPDFVMTDFAKYSRPAQLHIGFQALHQFCAQHNRPPRPRNEED 354

  Fly   261 DLELLR-----------GIRDELLPNSILGDEALGLIFA-QISPAVAVVGGVVAQEVIKVVTKLE 313
            ..||:.           .::.:.:...::  ..|..:.| .::|..|.:||:.||||:|..:...
  Rat   355 ATELVTLAQAVNARSPPAVQQDNVDEDLI--RKLAYVAAGDLAPINAFIGGLAAQEVMKACSGKF 417

  Fly   314 APHRNLFVFDPETC 327
            .|......||...|
  Rat   418 MPIMQWLYFDALEC 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aos1	NP_650198.1	Aos1_SUMO	19..>172	CDD:238769	62/152 (41%)
Aos1	NP_650198.1	ThiF	22..>167	CDD:279270	59/144 (41%)
Uba1	NP_001014102.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..46		3/12 (25%)
		Ube1	49..1055	CDD:273603	101/388 (26%)
		2 approximate repeats. /evidence=ECO:0000255	63..611		97/374 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810