DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aos1 and Sae1

DIOPT Version :9

Sequence 1:	NP_650198.1	Gene:	Aos1 / 41532	FlyBaseID:	FBgn0029512	Length:	337	Species:	Drosophila melanogaster
Sequence 2:	NP_001012063.1	Gene:	Sae1 / 308384	RGDID:	1306098	Length:	349	Species:	Rattus norvegicus

Alignment Length:	360	Identity:	138/360 - (38%)
Similarity:	201/360 - (55%)	Gaps:	38/360 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVVDMDTSETAVELTEAENELYDRQIRLWGLESQKRLRTAKILIAGLCGLGAEITKNIILSGVNS 65
            ||...:.|.....::|.|...|||||||||||:|||||.:::||.|:.||||||.||:||:||..
  Rat     1 MVEKEEVSGGGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLIVGMKGLGAEIAKNLILAGVKG 65

  Fly    66 VKLLDDKDVTEEDFCSQFLVPRESLNTNRAEASLTRARALNPMVDISADREPLKEKTSEFFGQFD 130
            :.:||.:.|:.||..:|||:...|:..|||||||.||:.||||||:..|.|.:::|...||.:||
  Rat    66 LTMLDHEQVSPEDLGAQFLIRTGSVGQNRAEASLERAQNLNPMVDVKVDTEDIEKKPESFFTEFD 130

  Fly   131 VVVVNGATNEELLRIDTICRDLGVKFIATDVWGTFGFYFASLQKHSYVEDVIKHKVVANSE---- 191
            .|.:...:.:.::::|.||....:||...||:|..|:.||:|.:|.:||:  |.||...|:
  Rat   131 AVCLTCCSKDVIIKVDQICHRNSIKFFTGDVFGYHGYTFANLGEHEFVEE--KTKVTKVSQGVED 193

  Fly   192 ----------------KKKKYETVSIPTQRDVDYPGYSAWLDFDVTEPSYLRKLKRNGPGVLLLS 240
                            .|||.....:.....||:.|..|           ...|||..|...||.
  Rat   194 GPDAKRAKLDSSETTMVKKKVLFCPVKEALAVDWSGEKA-----------QAALKRTAPDYFLLQ 247

  Fly   241 VLQKFRTTHKRDPSYKTREADLELLRGIRDELLPN-----SILGDEALGLIFAQISPAVAVVGGV 300
            ||.||||...|||:..:...|.|||..||:::..:     .:|.|:.:...|::::|..|||||:
  Rat   248 VLLKFRTDKGRDPTSDSYSEDAELLLQIRNDVFDSLGVSPDLLPDDFVRYCFSEMAPVCAVVGGI 312

  Fly   301 VAQEVIKVVTKLEAPHRNLFVFDPETCAGYVEAIG 335
            :|||::|.:::.:.||.|.|.||....:|.||.:|
  Rat   313 LAQEIVKALSQRDPPHNNFFFFDGMKGSGIVECLG 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aos1	NP_650198.1	Aos1_SUMO	19..>172	CDD:238769	74/152 (49%)
Aos1	NP_650198.1	ThiF	22..>167	CDD:279270	71/144 (49%)
Sae1	NP_001012063.1	Aos1_SUMO	19..344	CDD:238769	130/337 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345914
Domainoid	1	1.000	225	1.000	Domainoid score	I2456
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4019
Inparanoid	1	1.050	238	1.000	Inparanoid score	I3291
OMA	1	1.010	-	-		QHG54790
OrthoDB	1	1.010	-	-		D1180926at2759
OrthoFinder	1	1.000	-	-		FOG0003336
OrthoInspector	1	1.000	-	-		oto96563
orthoMCL	1	0.900	-	-		OOG6_102966
Panther	1	1.100	-	-	LDO	PTHR10953
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2228
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.770